Skip to main content
SpringerLink
Log in

Systemic candidiasis in babies with retinopathy of prematurity

  • Communications
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Fifteen premature babies developed systemic candidiasis during the administration of intravenous hyperalimentation in the Beilinson Neonatal Intensive Care Unit. Candida albicans was found in the blood cultures of all the babies and in the urine cultures of 66.7% of them. Repeated funduscopic examinations revealed no evidence of septic embolization in the retinal or choroidal circulation. It should be noted that acute retinopathy of prematurity (ROP) grade 2 or 3 was found in all the babies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Baley JE, Annable WL, Kliegman RM (1981) Candida endophthalmitis in premature infants. J Pediatr 98:458–461

    Google Scholar 

  2. Baley JE, Kliegman RM, Fanaroff AA (1984) Disseminated fungal infections in very low-birth-weight infants: clinical manifestations and epidemiology. Pediatrics 73:144–152

    Google Scholar 

  3. Baley JE, Kliegman RM, Fanaroff AA (1984) Disseminated fungal infections in very low-birth-weight infants: therapeutic toxicity. Pediatrics 73:153–157

    Google Scholar 

  4. Buchs (1985) Candida meningitis: a growing threat to premature and fullterm infants. Pediatr Infect Dis 4:122–123

    Google Scholar 

  5. Chesney PJ, Justman RA, Bogdanowicz WM (1978) Candida meningitis in newborn infants: a review and report of combined amphotericin B — flucytosine therapy. Johns Hopkins Med J 142:155–160

    Google Scholar 

  6. Cogan D (1963) Development and senescence of the human retinal vasculature. Trans Ophthalmol Soc UK 83:465–489

    Google Scholar 

  7. Committee for the classification of retinopathy of prematurity. An international classification of retinopathy of prematurity. (1984) Arch Ophthalmol 102:1130–1134

    Google Scholar 

  8. Donahue SP, Eller AW, Nguyen M, Yu V (1991) Ocular involvement in hospitalized patients with candidemia. Invest Ophthalmol Vis Sci (ARVO Suppl) 32:200–224

    Google Scholar 

  9. Edwards JE Jr, Foos RY, Montgomerie JZ, Guze LB (1974) Ocular manifestations of Candida septicemia: review of seventy-six cases of hematogenous Candida endophthalmitis. Medicine 53:47–75

    Google Scholar 

  10. Fishman LS, Griffin JR, Sapico FL, Hecht R (1972) Hematogenous Candida endophthalmitis — a complication of candidemia. N Engl J Med 286:675–681

    Google Scholar 

  11. Griffin JR, Pettie TH, Fishman LS, Foos RY (1973) Blood-borne Candida endophthalmitis. Arch Ophthalmol 89:450–456

    Google Scholar 

  12. Johnson DE, Thompson GR, Green TP, Ferrieri P (1984) Systemic candidiasis in very low-birth-weight infants (< 1500 g). Pediatrics 73:138–143

    Google Scholar 

  13. Keller MA, Sellers BB Jr, Melish ME, Kaplan TW, Miller KE, Mendoza SA (1977) Systemic candidiasis in infants. Am J Dis Child 131:1260–1263

    Google Scholar 

  14. Klein JD, Yamauchi T, Horlick SP (1972) Neonatal candidiasis, meningitis and arthritis: observations and a review of the literature. J Pediatr 81:31–34

    Google Scholar 

  15. Marier RL, Milligan E, Fan YD (1982) Elevated mannose levels detected by gas-lined chromatography in hydrolysates of serum from rats and humans with candidiasis. J Clin Microbiol 16:123–128

    Google Scholar 

  16. Palmer EA (1980) Endogenous Candida endophthalmitis in infants. Am J Ophthalmol 89:388–395

    Google Scholar 

  17. Patz A, Hoeck LE, De LaCruz E (1952) Studies on the effect of high oxygen administration in retrolental fibroplasia: a nursery observation. Am J Ophthalmol 35:1248–1253

    Google Scholar 

  18. Pick JJ, Knot EAR, Schooneveld MJ, Rietra PJGM (1988) Candidemia look at the eyes. Intensive Care Med 14:173–175

    Google Scholar 

  19. Remington JS, Gaines JD (1973) Diagnosis of deep infections with Candida: a study of Candida precipitins. Arch Intern Med 132:699–702

    Google Scholar 

  20. Stone HH, Kolb LD, Currie CA, Geheber CE, Cuzzell GZ (1974) Candida sepsis — pathogenesis and principles of treatment. Ann Surg 179:697–711

    Google Scholar 

  21. Tolentino FI, Schepens CL, Freeman HM (1976) Vitreoretinal disorders: diagnosis and management. Saunders, Philadelphia, p 1

    Google Scholar 

  22. Tolentino FI, Schepens CL, Freeman HM (1976) Vitreoretinal disorders: diagnosis and management. Saunders, Philadelphia, p 209

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Israel

    I. Kremer & I. Nissenkorn

  2. Neonatal Intensive Care Unit, Beilinson Medical Center, Petah Tiqva and Tel Aviv University Sackler Faculty of Medicine, Israel

    N. Naor & S. Davidson

  3. Research Department, Wills Eye Hospital, 19107, Philadelphia, PA, USA

    M. Arbizo

Authors
  1. I. Kremer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. N. Naor
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Davidson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Arbizo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. I. Nissenkorn
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kremer, I., Naor, N., Davidson, S. et al. Systemic candidiasis in babies with retinopathy of prematurity. Graefe's Arch Clin Exp Ophthalmol 230, 592–594 (1992). https://doi.org/10.1007/BF00181784

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00181784

Keywords

Search

Navigation