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Confounders in the Evaluation of Cardiac Fibrosis by Late Gadolinium Enhancement

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References

  1. Kindermann W, Scharhag J. High-level endurance exercise: are all potential ‘cons’ justified? Sports Med. doi:10.1007/s40279-016-0568-z.

  2. Regwan S, Hulten EA, Martinho S, et al. Marathon running as a cause of troponin elevation: a systematic review and meta-analysis. J Interv Cardiol. 2010;23(5):443–50.

    Article  PubMed  Google Scholar 

  3. Lindsay MM, Dunn FG. Biochemical evidence of myocardial fibrosis in veteran endurance athletes. Br J Sports Med. 2007;41(7):447–52.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Breuckmann F, Mohlenkamp S, Nassenstein K, et al. Myocardial late gadolinium enhancement: prevalence, pattern, and prognostic relevance in marathon runners. Radiology. 2009;251(1):50–7.

    Article  PubMed  Google Scholar 

  5. Mohlenkamp S, Lehmann N, Breuckmann F, et al. Running: the risk of coronary events: prevalence and prognostic relevance of coronary atherosclerosis in marathon runners. Eur Heart J. 2008;29(15):1903–10.

    Article  PubMed  Google Scholar 

  6. Wilson M, O’Hanlon R, Prasad S, et al. Diverse patterns of myocardial fibrosis in lifelong, veteran endurance athletes. J Appl Physiol (1985). 2011;110(6):1622–6.

    Article  CAS  Google Scholar 

  7. Karlstedt E, Chelvanathan A, Da Silva M, et al. The impact of repeated marathon running on cardiovascular function in the aging population. J Cardiovasc Magn Reson. 2012;14:58.

    Article  PubMed  PubMed Central  Google Scholar 

  8. O’Hanlon R, Wilson M, Wage R, et al. Troponin release following endurance exercise: is inflammation the cause? a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2010;12:38.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Trivax JE, Franklin BA, Goldstein JA, et al. Acute cardiac effects of marathon running. J Appl Physiol (1985). 2010;108(5):1148–53.

    Article  CAS  Google Scholar 

  10. Mousavi N, Czarnecki A, Kumar K, et al. Relation of biomarkers and cardiac magnetic resonance imaging after marathon running. Am J Cardiol. 2009;103(10):1467–72.

    Article  PubMed  Google Scholar 

  11. Prakken NH, Teske AJ, Cramer MJ, et al. Head-to-head comparison between echocardiography and cardiac MRI in the evaluation of the athlete’s heart. Br J Sports Med. 2012;46(5):348–54.

    Article  PubMed  Google Scholar 

  12. Franzen E, Mangold S, Erz G, et al. Comparison of morphological and functional adaptations of the heart in highly trained triathletes and long-distance runners using cardiac magnetic resonance imaging. Heart Vessels. 2013;28(5):626–31.

    Article  PubMed  Google Scholar 

  13. La Gerche A, Heidbuchel H. Can intensive exercise harm the heart? You can get too much of a good thing. Circulation. 2014;130(12):992–1002.

    Article  PubMed  Google Scholar 

  14. La Gerche A. Can intense endurance exercise cause myocardial damage and fibrosis? Curr Sports Med Rep. 2013;12(2):63–9.

    Article  PubMed  Google Scholar 

  15. Bohm P, Schneider G, Linneweber L, et al. Right and left ventricular function and mass in male elite master athletes: a controlled contrast-enhanced cardiovascular magnetic resonance study. Circulation. 2016;133(20):1927–35.

    Article  PubMed  Google Scholar 

  16. Bhella PS, Hastings JL, Fujimoto N, et al. Impact of lifelong exercise “dose” on left ventricular compliance and distensibility. J Am Coll Cardiol. 2014;64(12):1257–66.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Waterhouse DF, Ismail TF, Prasad SK, et al. Imaging focal and interstitial fibrosis with cardiovascular magnetic resonance in athletes with left ventricular hypertrophy: implications for sporting participation. Br J Sports Med. 2012;46(Suppl 1):i69–77.

    Article  PubMed  Google Scholar 

  18. Naylor LH, George K, O’Driscoll G, et al. The athlete’s heart: a contemporary appraisal of the ‘Morganroth hypothesis’. Sports Med. 2008;38(1):69–90.

    Article  PubMed  Google Scholar 

  19. Löllgen H, Löllgen R. Genetics, genetic testing and sports: aspects from sports cardiology. Genom Soc Policy. 2012;8:32–47.

    Google Scholar 

  20. Levine BD. Can intensive exercise harm the heart? The benefits of competitive endurance training for cardiovascular structure and function. Circulation. 2014;130(12):987–91.

    Article  PubMed  Google Scholar 

  21. Sanchis-Gomar F, Lucia A, Levine BD. Relationship between strenuous exercise and cardiac “morbimortality”: benefits outweigh the potential risks. Trends Cardiovasc Med. 2016;26(3):241–4.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Research Institute of the Hospital 12 de Octubre (‘i+12’), 6th Floor, Laboratories Sector, CAA Building, Avda. de Córdoba s/n, 28041, Madrid, Spain

    Fabian Sanchis-Gomar & Alejandro Lucia

  2. Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA

    Michael J. Joyner

  3. EFSMA and German Federation of Sports Medicine, Remscheid, Germany

    Herbert Löllgen

  4. European University, Madrid, Spain

    Alejandro Lucia

Authors
  1. Fabian Sanchis-Gomar
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  2. Michael J. Joyner
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  3. Herbert Löllgen
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  4. Alejandro Lucia
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Corresponding author

Correspondence to Fabian Sanchis-Gomar.

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Conflict of interests

Fabian Sanchis-Gomar, Michael Joyner, Herbert Löllgen, and Alejandro Lucia declare they have no potential conflicts of interest that are directly relevant to the content of this letter.

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Sanchis-Gomar, F., Joyner, M.J., Löllgen, H. et al. Confounders in the Evaluation of Cardiac Fibrosis by Late Gadolinium Enhancement. Sports Med 46, 1193–1194 (2016). https://doi.org/10.1007/s40279-016-0569-y

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  • DOI: https://doi.org/10.1007/s40279-016-0569-y

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