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Gallic Acid/2-Hydroxypropyl-β-cyclodextrin Inclusion Complexes Electrospun Nanofibrous Webs: Fast Dissolution, Improved Aqueous Solubility and Antioxidant Property of Gallic Acid

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Abstract

Gallic acid(GA) is a kind of natural polyphenolic compound, but its low aqueous solubility restricts its application in the fields of food and medicine. Cyclodextrin can form inclusion complexes with guest molecules(e.g., essential oils, food supplements) through cavities with special properties to improve aqueous solubility, thermal stability, and bioavailability of guest molecules. In this research, gallic acid/2-hydroxypropyl-β-cyclodextrin inclusion complexes(GA/2-HP-β-CD/ICs) were formed in a highly concentrated solution of 2-HP-β-CD. Bead-free and uniform nanofibrous webs(GA/2-HP-β-CD/IC-NWs) were produced successfully by electrospun GA/HP-β-CD/IC aqueous solution. The initial molar ratio(GA: 2-HP-β-CD=1:1) of GA/2-HP-β-CD/IC in the solutions was largely maintained in GA/2-HP-β-CD/IC-NW. The aqueous solubility of GA was enhanced and GA/2-HP-β-CD/IC-NW has displayed fast dissolution property. Furthermore, in comparison with GA powder, GA/2-HP-β-CD/IC-NW demonstrated improved antioxidant capacity. The results suggested that GA/2-HP-β-CD/IC-NW have broad application prospects as orally fast dissolution systems for food supplements.

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Acknowledgements

This work was supported by the Project of the Jilin Province Development and Reform Commission, China(No.2020C023-5) and the National Natural Science Foundation of China(No.31772058).

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Authors and Affiliations

  1. College of Food Science and Engineering, Jilin University, Changchun, 130025, P. R. China

    Yudong Song, Hui Huang & Jiali Li

  2. Key Lab of Groundwater Resources and Environment of Ministry of Education, College of New Energy and Environment, Jilin University, Changchun, 130021, P. R. China

    Hao Zhang & Yongxin Li

  3. Alan G. MacDiarmid Institute, College of Chemistry, Jilin University, Changchun, 130012, P. R. China

    Dayong He, Mei Yang, Hao Wang & Ce Wang

Authors
  1. Yudong Song
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  2. Hui Huang
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  3. Dayong He
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  4. Mei Yang
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  5. Hao Wang
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  6. Hao Zhang
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  7. Jiali Li
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  8. Yongxin Li
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  9. Ce Wang
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Correspondence to Yongxin Li.

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Supporting Information

40242_2021_14_MOESM1_ESM.docx

Gallic acid/2-hydroxypropyl-β-cyclodextrin inclusion complexes electrospun nanofibrous webs: Fast dissolution, improved aqueous solubility and antioxidant property of gallic acid

Supplementary material, approximately 11 MB.

Supplementary material, approximately 2.77 MB.

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Song, Y., Huang, H., He, D. et al. Gallic Acid/2-Hydroxypropyl-β-cyclodextrin Inclusion Complexes Electrospun Nanofibrous Webs: Fast Dissolution, Improved Aqueous Solubility and Antioxidant Property of Gallic Acid. Chem. Res. Chin. Univ. 37, 450–455 (2021). https://doi.org/10.1007/s40242-021-0014-0

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  • DOI: https://doi.org/10.1007/s40242-021-0014-0

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