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Long non-coding RNAs: emerging players in osteosarcoma

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Tumor Biology

Abstract

Osteosarcoma is the most common kind of primary bone tumors with high morbidity in infants and adolescents. While the molecular mechanism of osteosarcoma has gained considerable attention, the mechanisms underlying its initiation and progression remain unclear. Recent studies have discovered that long non-coding RNAs (lncRNAs) play an important role in multiply biological processes including cell development, differentiation, proliferation, invasion, and migration. Deregulated expression of lncRNAs has been found in cancers including osteosarcoma. This review summarized the deregulation and functional role of lncRNAs in osteosarcoma and their potential application for diagnosis and treatment of osteosarcoma.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (NSFC) (Grant Numbers: 81401847, 81272053 and 81330044).

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    Authors and Affiliations

    1. Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, China

      Zheng Li & Jianxiong Shen

    2. Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China

      Xin Yu

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    1. Zheng Li
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    Correspondence to Jianxiong Shen.

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    Zheng Li and Xin Yu contributed equally to this work.

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    Li, Z., Yu, X. & Shen, J. Long non-coding RNAs: emerging players in osteosarcoma. Tumor Biol. 37, 2811–2816 (2016). https://doi.org/10.1007/s13277-015-4749-4

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