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Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro

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Abstract

This study forms hydroxyapatite-silica ceramic structure, which can generate interconnected porous 3D models suitable as bone scaffold, using a novel selective laser sintering (SLS) technique. Hydroxyapatite (HA) powder and a silica sol are first mixed into slurries. After processing by SLS, the HA particles are embedded in the gelled silica matrix to form green parts. The processed parts are analyzed by scanning electron microscopy (SEM). The number of cells attached on this scaffold surface is obtained by the in vitro cultured cells test. The higher number of viable cells are obtained when the sintering temperature of the scaffold was 1200°C at day 4 of cell culturing. The proposed technology can be applied to generate a bone scaffold model of porous bio-ceramics for biomedicine.

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Authors and Affiliations

  1. Department of Mechanical Engineering, Lunghwa University of Science and Technology, 33306, Taoyuan, Taiwan

    Fwu-Hsing Liu

  2. School of Dental Technology, College of Oral Medicine, Taipei Medical University, 11031, Taipei, Taiwan

    Yung-Kang Shen

  3. Department of Chemical and Material Engineering, Lunghwa University of Science and Technology, Taoyuan, 33306, Taiwan

    Jeou-Long Lee

Authors
  1. Fwu-Hsing Liu
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  2. Yung-Kang Shen
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  3. Jeou-Long Lee
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Correspondence to Yung-Kang Shen.

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Liu, FH., Shen, YK. & Lee, JL. Selective laser sintering of a hydroxyapatite-silica scaffold on cultured MG63 osteoblasts in vitro. Int. J. Precis. Eng. Manuf. 13, 439–444 (2012). https://doi.org/10.1007/s12541-012-0056-9

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  • DOI: https://doi.org/10.1007/s12541-012-0056-9

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