Abstract
A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC50 values of 2.7 and 9.0 μM, respectively. The 13C-NMR data of euphoscopin F (2), epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.
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Tao, HW., Hao, XJ., Liu, PP. et al. Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia . Arch. Pharm. Res. 31, 1547–1551 (2008). https://doi.org/10.1007/s12272-001-2149-3
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DOI: https://doi.org/10.1007/s12272-001-2149-3