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A potential greener protocol for peptide coupling reactions using recyclable/reusable ionic liquid [\(\hbox {C}_{4}\hbox {-DABCO}][\hbox {N(CN)}_{2}\)]

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Abstract

Abstract

Development of greener methodologies in synthetic organic chemistry has brought awareness in recent decades due to the ecological performance of green solvent media and catalytic systems. Here, we carried out the peptide bond formation reaction in one of the environmentally secure solvents, ‘ionic liquids’ in the presence of coupling reagent and in the absence of external base at room temperature, affording dipeptides in good to excellent yields.

GRAPHICAL ABSTRACT

SYNOPSIS We carried out the peptide bond formation reaction in ionic liquids in the presence of a coupling reagent at room temperature, in the absence of an external base, affording dipeptides in good to excellent yields.

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Acknowledgements

M.K. is thankful to UGC for UGC-BSR fellowship. D.S. is thankful to DST, New Delhi, India for a research Grant [No. EMR/2016/002345]. The authors acknowledge the Department of Science and Technology for financial assistance under DST-FIST programme and UGC, New Delhi for Special Assistance Programme (UGC-SAP) to the Department of Chemistry, Dibrugarh University.

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Authors and Affiliations

  1. Department of Chemistry, Dibrugarh University, Dibrugarh, Assam, 786 004, India

    Manashjyoti Konwar & Diganta Sarma

  2. Centre for Materials for Electronics Technology, Pashan Road, Pune, Maharashtra, 411 008, India

    Nageshwar D Khupse

  3. Analytical Chemistry Division, CSIR-North East Institute of Science and Technology, Jorhat, Assam, 785 006, India

    Prakash J Saikia

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  1. Manashjyoti Konwar
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  2. Nageshwar D Khupse
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Correspondence to Diganta Sarma.

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Konwar, M., Khupse, N.D., Saikia, P.J. et al. A potential greener protocol for peptide coupling reactions using recyclable/reusable ionic liquid [\(\hbox {C}_{4}\hbox {-DABCO}][\hbox {N(CN)}_{2}\)]. J Chem Sci 130, 53 (2018). https://doi.org/10.1007/s12039-018-1461-0

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