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Oxygen Delivery Approaches to Augment Cell Survival After Myocardial Infarction: Progress and Challenges

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Abstract

Myocardial infarction (MI), triggered by blockage of a coronary artery, remains the most common cause of death worldwide. After MI, the capability of providing sufficient blood and oxygen significantly decreases in the heart. This event leads to depletion of oxygen from cardiac tissue and consequently leads to massive cardiac cell death due to hypoxemia. Over the past few decades, many studies have been carried out to discover acceptable approaches to treat MI. However, very few have addressed the crucial role of efficient oxygen delivery to the injured heart. Thus, various strategies were developed to increase the delivery of oxygen to cardiac tissue and improve its function. Here, we have given an overall discussion of the oxygen delivery mechanisms and how the current technologies are employed to treat patients suffering from MI, including a comprehensive view on three major technical approaches such as oxygen therapy, hemoglobin-based oxygen carriers (HBOCs), and oxygen-releasing biomaterials (ORBs). Although oxygen therapy and HBOCs have shown promising results in several animal and clinical studies, they still have a few drawbacks which limit their effectiveness. More recent studies have investigated the efficacy of ORBs which may play a key role in the future of oxygenation of cardiac tissue. In addition, a summary of conducted studies under each approach and the remaining challenges of these methods are discussed.

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Fig. 1

Reprinted with permission from [59] under the Creative Commons CC-BY-NC-ND 4.0 license

Fig. 2

Reprinted with permission from [59] under the Creative Commons CC-BY-NC-ND 4.0 license

Fig. 3

Reprinted with permission from [84] under the Creative Commons Attribution License

Fig. 4
Fig. 5

Reprinted with permission from [86] under a Creative Commons Attribution 4.0 International License

Fig. 6

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Abbreviations

MI:

Myocardial infarction

HBOCs:

Hemoglobin-based oxygen carriers

ORBs:

Oxygen-releasing biomaterials

IGF-1:

Insulin-like growth factor

PDGF:

Platelet-derived growth factor

ATP:

Adenosine triphosphate

AMI:

Acute myocardial infarction

FIO2 :

Fraction of inspired oxygen

HBO:

Hyperbaric oxygen

MSCs:

Mesenchymal stem cells

IR:

Ischemia–reperfusion

WR/WLV:

Weight of risk/weight of left ventricle

WI/WLV:

Weight of infarct/weight of left ventricle

ROS:

Reactive oxygen species

PolyPHb:

Polymerized human placenta hemoglobin

PDMS:

Polydimethylsiloxane

3D:

Three-dimensional

PFO:

Perfluorooctane

hPDCs:

Human periosteal cells

SPO:

Sodium percarbonate

CPO:

Calcium peroxide

T1D:

Type 1 diabetes

β cells:

Beta cells

CSPs:

Cardiac side population cells

CPO-GelMA:

Calcium peroxide laden gelatin methacryloyle

PFC:

Perfluorocarbon

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Acknowledgements

The authors would like to thank the National Institute for Medical Research Development (NIMAD) (Grant No. 972838) for the financial support of this research project.

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Authors and Affiliations

  1. School of Metallurgy and Materials Engineering, College of Engineering, University of Tehran, P.O. Box: 11155-4563, Tehran, Iran

    Alireza Jenabi, Rouhollah Mehdinavaz Aghdam & S. A. Seyyed Ebrahimi

  2. Research Center for Advanced Technologies in Cardiovascular Medicine, Cardiovascular, Tehran Heart Center Hospital, Tehran University of Medical Sciences, Tehran, Iran

    Seyed Hossein Ahmadi Tafti

  3. Biomaterials and Organ Engineering Group, Centre for Biomaterials, Cellular and Molecular Theranostics, School of Mechanical Engineering, Vellore Institute of Technology, Vellore, 632014, India

    Sasirekha Krishnan, K. Shoma Suresh & Murugan Ramalingam

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  1. Alireza Jenabi
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Correspondence to Rouhollah Mehdinavaz Aghdam or Murugan Ramalingam.

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Jenabi, A., Mehdinavaz Aghdam, R., Ebrahimi, S.A.S. et al. Oxygen Delivery Approaches to Augment Cell Survival After Myocardial Infarction: Progress and Challenges. Cardiovasc Toxicol 22, 207–224 (2022). https://doi.org/10.1007/s12012-021-09696-5

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