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Surgical Treatment of Completely Endophytic Renal Tumor: a Systematic Review

  • Kidney Diseases (G Ciancio, Section Editor)
  • Published:
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Abstract

Purpose of Review

An endophytic renal tumor represents a special surgical challenge in terms of location and safe removal. For this reason we wanted to review the existing literature on this subject.

Recent Findings

In high-activity robotic centers, robot-assisted partial nephrectomy (RAPN) is a safe and efficacious surgical approach for completely endophytic renal tumors. As research innovation, the application of the radio-guided occult lesion localization technique (ROLL) facilitates the location and complete excision of the tumor during surgery.

Summary

There are few studies that specifically report the experience with completely endophytic renal tumors. The endophytic tumor is usually smaller than exophytic. Frequently it represents a high complexity value in the different Score systems reported in the last decade. This surgery should be performed by experienced urologists regardless of the surgical approach they prefer (open, laparoscopic, or robotic). It is necessary to develop new techniques for intraoperative easy localization and intraoperative evaluation of surgical margins.

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References

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  1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2018. CA Cancer J Clin. 2018;68(1):7–30. https://doi.org/10.3322/caac.21442.

    Article  PubMed  Google Scholar 

  2. Hollingsworth JM, Miller DC, Daignault S, Hollenbeck BK. Rising incidence of small renal masses: a need to reassess treatment effect. J Natl Cancer Inst. 2006;98(18):1331–4. https://doi.org/10.1093/jnci/djj362.

    Article  PubMed  Google Scholar 

  3. Johnson DC, Vukina J, Smith AB, Meyer AM, Wheeler SB, Kuo TM, et al. Preoperatively misclassified, surgically removed benign renal masses: a systematic review of surgical series and United States population level burden estimate. J Urol. 2015;193(1):30–5. https://doi.org/10.1016/j.juro.2014.07.102.

    Article  PubMed  Google Scholar 

  4. Kane CJ, Mallin K, Ritchey J, Cooperberg MR, Carroll PR. Renal cell cancer stage migration: analysis of the National Cancer Data Base. Cancer. 2008;113(1):78–83. https://doi.org/10.1002/cncr.23518.

    Article  PubMed  Google Scholar 

  5. Smaldone MC, Egleston B, Hollingsworth JM, Hollenbeck BK, Miller DC, Morgan TM, et al. Understanding treatment disconnect and mortality trends in renal cell carcinoma using tumor registry data. Med Care. 2017;55:398–404. https://doi.org/10.1097/MLR.0000000000000657.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Thompson RH, Kurta JM, Kaag M, Tickoo SK, Kundu S, Katz D, et al. Tumor size is associated with malignant potential in renal cell carcinoma cases. J Urol. 2009;181(5):2033–6. https://doi.org/10.1016/j.juro.2009.01.027.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Novick AC, Streem S, Montie JE, Pontes JE, Siegel S, Montague DK, et al. Conservative surgery for renal cell carcinoma: a single-center experience with 100 patients. J Urol. 1989;141(4):835–9.

    Article  CAS  Google Scholar 

  8. •• Kara O, Maurice MJ, Malkoc E, Ramirez D, Nelson RJ, Caputo PA, et al. Comparison of robot-assisted and open partial nephrectomy for completely endophytic renal tumours: a single centre experience. BJU Int. 2016;118(6):946–51. https://doi.org/10.1111/bju.13572 A big series showing similar results of open and robotic partial nephrectomy in endophytic tumors.

    Article  PubMed  Google Scholar 

  9. • Autorino R, Khalifeh A, Laydner H, Samarasekera D, Rizkala E, Eyraud R, et al. Robot-assisted partial nephrectomy (RAPN) for completely endophytic renal masses: a single institution experience. BJU Int. 2014;113(5):762–8. https://doi.org/10.1111/bju.12455 First report of RAPN for endophytic renal tumors with an important number of patients.

    Article  PubMed  Google Scholar 

  10. Chung BI, Lee UJ, Kamoi K, Canes DA, Aron M, Gill IS. Laparoscopic partial nephrectomy for completely intraparenchymal tumors. J Urol. 2011;186(6):2182–7. https://doi.org/10.1016/j.juro.2011.07.106.

    Article  PubMed  Google Scholar 

  11. Betancourt Hernández JA, Vera Donoso C, Martinez-Sarmiento M, Monserrat JJ, Bello Jarque P, Boronat Tormo F. Application of the radio-guided occult lesion localization technique for renal lumpectomy: from the laboratory to the patient. Clin Nucl Med. 2017;42(11):e467–8. https://doi.org/10.1097/RLU.0000000000001811.

    Article  PubMed  Google Scholar 

  12. •• Harke NN, Mandel P, Witt JH, Wagner C, Panic A, Boy A, et al. Are there limits of robotic partial nephrectomy? TRIFECTA outcomes of open and robotic partial nephrectomy for completely endophytic renal tumors. J Surg Oncol. 2018;118(1):206–11. https://doi.org/10.1002/jso.25103 A big cohort encouraging open or robotic partial nephrectomy in endophytic tumors achieving good TRIFECTA criteria.

    Article  PubMed  Google Scholar 

  13. Di Pierro GB, Tartaglia N, Aresu L, Polara A, Cielo A, Cristini C, et al. Laparoscopic partial nephrectomy for endophytic hilar tumors: feasibility and outcomes. Eur J Surg Oncol. 2014;40(6):769–74. https://doi.org/10.1016/j.ejso.2013.11.023.

    Article  PubMed  Google Scholar 

  14. Zapala P, Dybowski B, Miazek N, Radziszewski P. Open partial nephrectomy for entirely intraparenchymal tumors: a matched case-control study of oncologic outcome and complication rate. Int Braz J Urol. 2017;43(2):209–15. https://doi.org/10.1590/S1677-5538.IBJU.2016.0040.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Nadu A, Goldberg H, Lubin M, Baniel J. Laparoscopic partial nephrectomy (LPN) for totally intrarenal tumours. BJU Int. 2013;112(2):E82–6. https://doi.org/10.1111/bju.12168.

    Article  PubMed  Google Scholar 

  16. Weight CJ, Lane BR, Gill IS. Laparoscopic partial nephrectomy for selected central tumours: omitting the bolster. BJU Int. 2007;100(2):375–8.

    Article  Google Scholar 

  17. Dall'Oglio MF, Ballarotti L, Passerotti CC, Paluello DV, Colombo JR Jr, Crippa A, et al. Anatrophic nephrotomy as nephron-sparing approach for complete removal of intraparenchymal renal tumors. Int Braz J Urol. 2012;38(3):356–61.

    Article  Google Scholar 

  18. Komninos C, Shin TY, Tuliao P, Kim DK, Han WK, Chung BH, et al. Robotic partial nephrectomy for completely endophytic renal tumors: complications and functional and oncologic outcomes during a 4-year median period of follow-up. Urology. 2014;84(6):1367–73. https://doi.org/10.1016/j.urology.2014.08.012.

    Article  PubMed  Google Scholar 

  19. Mullerad M, Kastin A, Adusumilli PS, Moskovitz B, Sabo E, Nativ O. Comparison of nephron-sparing surgery in central versus peripheral renal tumors. Urology. 2005;65(3):467–72.

    Article  Google Scholar 

  20. Black P, Filipas D, Fichtner J, Hohenfellner R, Thüroff JW. Nephron sparing surgery for central renal tumors: experience with 33 cases. J Urol. 2000;163(3):737–43.

    Article  CAS  Google Scholar 

  21. Santos VE, Meduna RR, Bachega W Jr, Guimarães GC. Completely endophytic renal tumor: a laparoscopic approach. Int Braz J Urol. 2018;44:1050. https://doi.org/10.1590/S1677-5538.IBJU.2017.0534.

    Article  PubMed  PubMed Central  Google Scholar 

  22. Kutikov A, Uzzo RG. The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol. 2009;182(3):844–53. https://doi.org/10.1016/j.juro.2009.05.035.

    Article  PubMed  Google Scholar 

  23. Ficarra V, Novara G, Secco S, Macchi V, Porzionato A, De Caro R, et al. Preoperative aspects and dimensions used for an anatomical (PADUA) classification of renal tumours in patients who are candidates for nephron-sparing surgery. Eur Urol. 2009;56(5):786–93. https://doi.org/10.1016/j.eururo.2009.07.040.

    Article  PubMed  Google Scholar 

  24. • Mohapatra A, Potretzke AM, Weaver J, Anderson BG, Vetter J, Figenshau RS. Trends in the management of small renal masses: a survey of members of the Endourological Society. J Kidney Cancer VHL. 2017;4(3):10–9. https://doi.org/10.15586/jkcvhl.2017.82 eCollection 2017. This work shows the trends and evolution of surgical techniques among urologists in USA.

    Article  PubMed  PubMed Central  Google Scholar 

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Correspondence to César D. Vera-Donoso.

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Conflict of Interest

Javier Perez-Ardavin, Jose Vicente Sanchez-Gonzalez, Manuel Martinez-Sarmiento, Juan Jose Monserrat-Monfort, Jorge García-Olaverri, Francisco Boronat-Tormo, and César D. Vera-Donoso each declare no potential conflicts of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Perez-Ardavin, J., Sanchez-Gonzalez, J.V., Martinez-Sarmiento, M. et al. Surgical Treatment of Completely Endophytic Renal Tumor: a Systematic Review. Curr Urol Rep 20, 3 (2019). https://doi.org/10.1007/s11934-019-0864-x

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