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Potential Dopamine-1 Receptor Stimulation in Hypertension Management

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Abstract

The role of dopamine receptors in blood pressure regulation is well established. Genetic ablation of both dopamine D1-like receptor subtypes (D1, D5) and D2-like receptor subtypes (D2, D3, D4) results in a hypertensive phenotype in mice. This review focuses on the dopamine D1-like receptor subtypes D1 and D5 (especially D1 receptors), as they play a major role in regulating sodium homeostasis and blood pressure. Studies mostly describing the role of renal dopamine D1-like receptors are included, as the kidneys play a pivotal role in the maintenance of sodium homeostasis and the long-term regulation of blood pressure. We also attempt to describe the interaction between D1-like receptors and other proteins, especially angiotensin II type 1 and type 2 receptors, which are involved in the maintenance of sodium homeostasis and blood pressure. Finally, we discuss a new concept of renal D1 receptor regulation in hypertension that involves oxidative stress mechanisms.

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Acknowledgments

NIH/NIA AG29904 to MA and AG25056 to MFL. NIH/NIDDK DK61578 and Norman Hackerman Advanced Research Program, Texas, to TH.

Disclosure

No potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Heart and Kidney Institute, College of Pharmacy, University of Houston, Houston, TX, 77204, USA

    Mohammad Asghar, Mustafa F. Lokhandwala & Tahir Hussain

  2. Human Anatomy Section, School of Drug Sciences and Health Products, University of Camerino, Camerino, 62032, Italy

    Seyed K. Tayebati

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  1. Mohammad Asghar
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  2. Seyed K. Tayebati
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  3. Mustafa F. Lokhandwala
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  4. Tahir Hussain
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Correspondence to Mohammad Asghar or Tahir Hussain.

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Asghar, M., Tayebati, S.K., Lokhandwala, M.F. et al. Potential Dopamine-1 Receptor Stimulation in Hypertension Management. Curr Hypertens Rep 13, 294–302 (2011). https://doi.org/10.1007/s11906-011-0211-1

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  • DOI: https://doi.org/10.1007/s11906-011-0211-1

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