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Nutrigénomique: cas pour un terrain commun à la maladie cardiovasculaire et au cancer

Nutrigenomics: a case for the common soil between cardiovascular disease and cancer

  • Nutrigénomique
  • Published:
Bio tribune magazine

Résumé

La limite entre la santé et la maladie est souvent établie par un équilibre complexe entre deux éléments, génétique d’une part et style de vie de l’autre. Mieux le comprendre signifie mettre de nouvelles armes, souvent essentielles, à la portée des médecins et de leurs patients. Ceci implique aussi l’adaptation de thérapies afin de trouver le médicament approprié pour le patient et la meilleure stratégie de prévention qui sera efficace pour lui ou pour elle. La nutrigénomique est une approche pour individualiser ou personnaliser l’alimentation et la nutrition, et la santé en fin de compte, en ajustant l’alimentation au génotype individuel. Dans cette revue, nous présentons l’interaction entre certains polymorphismes génétiques et un certain régime alimentaire, et un accroissement du risque cardiovasculaire ou d’un cancer. Il est certainement clair, à présent, qu’un grand nombre de composants des aliments bioactifs peut comporter un risque ou présenter une protection aux différents stades du processus de formation de l’athérosclérose et du cancer. Nous fournissons, dans cette étude, quelques exemples d’interactions gène/alimentation qui sont pertinents pour le risque cardiovasculaire et pour le cancer, car un terrain commun pourrait exister entre la genèse de la maladie cardiovasculaire et certains types de cancers (principalement ceux du tractus gastro-intestinal et ceux dépendant des hormones).

Abstract

The border between health and disease is often set by a complex equilibrium between two elements genetics on one hand, lifestyle on the other, To know it better, means to give new weapons, often crucial, in the hands of the doctors and their patients. It also means to adjust therapies, to find out which drug is good for a patient and which prevention strategy will work better for him/her. Nutrigenomics is an approach to individualize or personalize food and nutrition, and ultimately health, by tailoring the food to the individual genotype. In this review, we present the interaction between certain genetic polymorphisms and diet and increased cardiovascular or cancer risk. It is, indeed, now clear that a large number of bioactive food components may provide risk or protection at several stages of both atherosclerosis and cancer formation processes. We are giving here few examples of gene-food interactions relevant for both the risk of cardiovascular disease and cancer, since a common soil could exist in the genesis of cardiovascular disease and of some types of cancer (mainly gastrointestinal tract and hormonedependent).

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  1. Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, « John Paul II » Centre for High Technology Research and Education in Biomedical Sciences, Catholic University, Largo Gemelli, 1, 86100, Campobasso, Italie

    L. Lacoviello, I. Santimone, M. C. Latella, G. de Gaetano & M. B. Donati

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  1. L. Lacoviello
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  2. I. Santimone
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  3. M. C. Latella
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Lacoviello, L., Santimone, I., Latella, M.C. et al. Nutrigénomique: cas pour un terrain commun à la maladie cardiovasculaire et au cancer. Bio trib. mag. 30, 41–46 (2009). https://doi.org/10.1007/s11834-009-0105-6

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