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Alterations of Gastric Emptying Features Following Laparoscopic Sleeve Gastrectomy in Chinese Patients with Obesity: a Self-Controlled Observational Study

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Abstract

Background

Laparoscopic sleeve gastrectomy (LSG) has become an increasingly popular metabolic surgical procedure. Alteration in motor gastric function is a fundamental feature following LSG but still remains controversial.

Purpose

To determine the gastric emptying time 3 month after LSG, correlations between gastric emptying time and body weight, weight loss, and glycemia levels, alongside determining predictive factors of weight loss at the 3-month follow-up.

Materials and Methods

Twenty-one patients were recruited in this study. Gastric emptying time was measured using a standard solid-phase gastric emptying scan at both baseline and 3 months after LSG. Paired sample t tests and a general linear model with repeated measures were applied to investigate the alterations in major parameters after surgery. Univariate analyses were performed to evaluate the factors predicting weight loss at the 3-month follow-up.

Results

Compared with baseline levels, gastric emptying time, body weight, and HbA1c levels decreased significantly at 3 months after LSG (P < 0.001). Significant positive correlations were detected between HbA1c levels and gastric emptying time at baseline (P = 0.03). Significant positive correlations were detected between HbA1c levels at baseline and change in gastric emptying time (P = 0.03). Univariate logistic regression revealed a lower baseline BMI level to be independently associated with %EWL (P < 0.001).

Conclusions

The rate of gastric emptying increased following LSG. Patients with a higher risk of type 2 diabetes at baseline had longer gastric emptying times prior to treatment and significantly shortened emptying times following surgery.

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Acknowledgments

The authors would like to thank all of the involved study investigators, staffs, clinicians, nurses, and technicians for dedicating their time and skills to the completion of this study.

Funding

This study was supported by National Key Technologies R&D Program (Grant No. 2015BAI13B09); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (Grant No. ZYLX201504); Research Foundation of Beijing Friendship Hospital, Capital Medical University (Grant No. yyqdkt 2017-31); and Wu Jieping Medical Foundation (Grant No. 320.2710.1813).

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Author notes

  1. Mengyi Li and Yang Liu contributed equally to this work.

Authors and Affiliations

  1. Department of General Surgery, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Diseases, No. 95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China

    Mengyi Li, Yang Liu, Lan Jin, Lixue Wang, Kaixin Zhao, Wei Xu & Zhongtao Zhang

  2. Department of Nuclear Medicine, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China

    Wei Wang & Jigang Yang

  3. National Clinical Research Center for Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-an Road, Xi-Cheng District, Beijing, 100050, China

    Na Zeng

Authors
  1. Mengyi Li
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  2. Yang Liu
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  3. Lan Jin
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  4. Wei Wang
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  5. Na Zeng
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  6. Lixue Wang
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  7. Kaixin Zhao
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  8. Wei Xu
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  9. Zhongtao Zhang
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Corresponding authors

Correspondence to Zhongtao Zhang or Jigang Yang.

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Conflict of Interest

The authors declare that they have no conflict of interest.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in this study.

Statement of Human and Animal Rights

This study was performed in accordance with the principles of the Declaration of Helsinki and was approved by the Ethics Committees of Beijing Friendship Hospital, Capital Medical University.

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Li, M., Liu, Y., Jin, L. et al. Alterations of Gastric Emptying Features Following Laparoscopic Sleeve Gastrectomy in Chinese Patients with Obesity: a Self-Controlled Observational Study. OBES SURG 29, 617–625 (2019). https://doi.org/10.1007/s11695-018-3571-7

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  • DOI: https://doi.org/10.1007/s11695-018-3571-7

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