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Variations of human cerebral and ocular blood flow during exposure to multi-axial accelerations

A mathematical modeling study

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Abstract

Human hemodynamic responses during exposure to multi-axial acceleration was a relatively new topic in the fields of acceleration physiology. This study aimed to focus on these responses, especially variations of blood perfusion to brain and eyes, through mathematical modeling. A mathematical model was established using lumped parameter methods, containing compartments of four heart chambers, systemic arteries and veins, circulation of typical systemic organs, and some compartments for pulmonary circulation, together with autonomic regulation considered. This model was firstly validated by using experimental data from experiment of posture change and centrifuge tests of +Gz accelerations, and then applied to analyze human hemodynamic responses to typical multi-axial accelerations. Validation results demonstrated the mathematical model could generate reasonable responses of human cardiovascular system during posture change and exposure to +Gz accelerations. Simulation results of hemodynamic responses to multi-axial accelerations depicted Gy induced significant differences of blood flow to the left and right eyes. And some contour maps were generated based on these results, which provided a quick way to estimate blood flow variations in brain and eyes during exposure to different accelerations.

This study aimed to focus on variations of blood perfusion to brain and eyes during exposure to typical multi-axial accelerations through mathematical modeling. This model was firstly validated by using experimental data from experiment of posture change and centrifuge tests of +Gz accelerations, and then applied to analyze human hemodynamic responses to typical multi-axial accelerations. Simulation results of hemodynamic responses to multi-axial accelerations depicted Gy induced significant differences of blood flow to the left and right eyes. And contour maps that generated based on these results provided a quick way to estimate blood flow variations in brain and eyes during exposure to different accelerations.

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Funding

This work was supported by the Aeronautical Science Foundation of China (2017ZC51024), the Defense Industrial Technology Development Program (JCKY2016601B009), the National Natural Science Foundation of China (12072018, 11602013), the 111 Project 345 (B13003).

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Authors and Affiliations

  1. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China

    Weipeng Li, Bitian Wang, Yawei Wang, Xiaoyu Liu, Wentao Feng, Tianya Liu, Zhujun Sun, Yu Liu & Yubo Fan

  2. College of Veterinary Medicine, China Agricultural University, Beijing, 100083, People’s Republic of China

    Tianya Liu

  3. Air Force Special Medical Center, Beijing, 100142, China

    Songyang Liu

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  1. Weipeng Li
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  2. Bitian Wang
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  3. Yawei Wang
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  4. Xiaoyu Liu
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Correspondence to Yawei Wang or Yubo Fan.

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Weipeng Li and Bitian Wang contributed equally to this work.

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Li, W., Wang, B., Wang, Y. et al. Variations of human cerebral and ocular blood flow during exposure to multi-axial accelerations. Med Biol Eng Comput 60, 471–486 (2022). https://doi.org/10.1007/s11517-021-02472-1

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