Abstract
The aim of this study was to characterize the differences between the prediction of GFR with Cockcroft-Gault formula (CG=(140–age)/(72×PCr (mg/ml), for females multiplied by 0.85) and the new formula based on the multicenter trial of the Modification of Diet in Renal Diseases (MDRD=186 × P −1.154Cr × age−0.203; 0.742 if patient is female) in elderly subjects. The study involved 100 individuals aged 65–111 years (mean age 88.3±14.7; 79 females and 21 males). In all subjects GFR was estimated according to both formulas mentioned above and expressed in ml/min/1.73 m2. Thereafter we calculated the difference between MDRD and CG (MDRD-CG) and analyzed its determinants in every subject. Mean GFR, obtained with MDRD was 76.0±24.0, whereas according to CG 67.9±18.6 (p < 0.0001). However, the mean MDRD-CG was up to 30.0±26.6 which means that MDRD results were much higher in comparison with CG. Using the multiple linear regression analysis we showed that MDRD-CG strongly depend on age (p < 0.0001), BMI (p < 0.0001) and serum creatinine concentration (p<0.0001). However, the gender has not effect on MDRD-CG value. The values of MDRD-CG strongly and positively correlated with age (r=0.7027, p < 0.0001) and negatively both with body mass index (r=−0.7171, p < 0.0001) and serum creatinine (r=−0.5590, p < 0.0001). In summary, our results show that the difference between MDRD and CG strongly depends on age, BMI and Scr. Investigators should be aware of these differences and take it into account in elderly.
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References
FAW Kemperman R Kreidet L Arisz (2002) ArticleTitleFormula-derived prediction of the glomerular filtration rate from plasma creatinine concentration Nephron 91 547 Occurrence Handle12138254 Occurrence Handle1:CAS:528:DC%2BD38XlsFOnsb0%3D Occurrence Handle10.1159/000065012
DW Cockroft MH Gault (1976) ArticleTitlePrediction of creatinine clearance from serum creatinine Nephron 16 31
DG Waller JS Fleming B Ramsay J Gray (1991) ArticleTitleThe accuracy of creatinine clearance with and without urine collections as a measure of glomerular filtration rate Postgrad Med 67 42 Occurrence Handle1:STN:280:DyaK3M3nvFGqug%3D%3D Occurrence Handle10.1136/pgmj.67.783.42
TH Glodberg MS Finkkelstein (1987) ArticleTitleDifficulties in estimating glomerular filtration rate in the elderly Arch Intern Med 147 1430 Occurrence Handle10.1001/archinte.147.8.1430
D Baracskay D Jarjoura A Cugino D Blend GW Rutecki FC Whittier (1997) ArticleTitleGeriatric renal function: estimating glomerular filtration in an ambulatory elderly population Clin Nephrol 47 IssueID4 222 Occurrence Handle9128788 Occurrence Handle1:STN:280:DyaK2s3nsVOrsQ%3D%3D
K Wieczorowska-Tobis M Mossakowska Z Niemir A Breborowicz DG Oreopoulos (2002) ArticleTitleDiscrepancies in creatinine clearance in centenarians when calculated by two different mathematical formulas Nephrol Dial Transplant 17 IssueID12 2274 Occurrence Handle12454252 Occurrence Handle1:CAS:528:DC%2BD38XptlOhtrs%3D Occurrence Handle10.1093/ndt/17.12.2274
K Wieczorowska-Tobis ZI Niemir P Guzik M Mossakowska (2004) ArticleTitleKidney function estimated with different formulas in centenarians Rocz Akad Med Bialymst 49 219 Occurrence Handle15631347 Occurrence Handle1:STN:280:DC%2BD2M%2FgsFyqtg%3D%3D
AS Levey JP Bosch JB Lewis T Greene N Rogers D Roth (1999) ArticleTitleA more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group Ann Intern Med 130 461 Occurrence Handle10075613 Occurrence Handle1:CAS:528:DyaK1MXitFChs7k%3D
NJ Noortgate ParticleVan Den WH Janssens JR Delanghe MB Afschrift NH Lameire (2002) ArticleTitleSerum cystatin C concentration compared with other markers of glomerular filtration rate in the old J Am Geriatr Soc 50 IssueID7 1278 Occurrence Handle10.1046/j.1532-5415.2002.50317.x
EJ Lamb MC Webb DE Simpson AJ Coakley DJ Newman SE O’Riordan (2003) ArticleTitleEstimation of glomerular filtration rate in older patients with chronic renal insufficiency: is the modification of diet in renal disease formula an improvement? J Am Geriatr Soc 51 1012 Occurrence Handle12834524 Occurrence Handle10.1046/j.1365-2389.2003.51330.x
D Dubois EF Dubois (1916) ArticleTitleClinical calorimetry. A formula to estimate the approximate surface in height and weight be known; Arch Intern Med 17 863 Occurrence Handle1:CAS:528:DyaC28XhtVCnug%3D%3D
JM Bland DG Altman (1986) ArticleTitleStatistical methods for assessing agreement between two methods of clinical measurement Lancet 1 307 Occurrence Handle2868172 Occurrence Handle1:STN:280:DyaL287hslWqsQ%3D%3D
D Fliser E Ritz (2001) ArticleTitleSerum cystatin C concentration as a marker of renal dysfunction in the elderly Am J Kidney Dis 37 79 Occurrence Handle11136171 Occurrence Handle1:CAS:528:DC%2BD3MXls1Giuw%3D%3D
H Burkhardt G Bojarsky N Grety R Gladisch (2002) ArticleTitleCreatinine clearance, Cockcroft-Gault formula and cystatin C: estimators of true glomerular filtration rate in the elderly? Gerontology 48 140 Occurrence Handle11961366 Occurrence Handle10.1159/000052832
DR Luke CE Halstenson JA Opsahl GR Matzke (1990) ArticleTitleValidity of creatinine clearance estimates in the assessment of renal function Clin Pharmacol Ther 48 503 Occurrence Handle2225710 Occurrence Handle1:STN:280:DyaK3M%2FjtVemtw%3D%3D Occurrence Handle10.1038/clpt.1990.186
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Wieczorowska-Tobis, K., Niemir, Z.I., Guzik, P. et al. Difference in estimated GFR with two different formulas in elderly individuals. Int Urol Nephrol 38, 381–385 (2006). https://doi.org/10.1007/s11255-006-0065-7
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DOI: https://doi.org/10.1007/s11255-006-0065-7