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Impact of functional status on 6-month mortality in elderly patients with acute venous thromboembolism: results from a prospective cohort

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Abstract

Functional status linked to a poor outcome in a broad spectrum of medical disorders. Barthel Activities of Daily Life Index (BADLI) is one of the most extended tools to quantify functional dependence. Whether BADLI can help to predict outcomes in elderly patients with acute venous thromboembolism (VTE) is unknown. The current study aimed to ascertain the influence of BADLI on 6-month all-cause mortality in aged patients with VTE. This is a prospective observational study. We included consecutive patients older than 75-year-old with an acute VTE between April 2015 and April 2017. We analyzed several variables as mortality predictors, including BADLI-measured functional status. Afterward, we performed a multivariate analysis, using logistic regression, to identify all-cause mortality independent predictive factors. Two hundred and two subjects were included. Thirty-five (17%) patients died in the first 6 months. The leading cause of death was cancer (59%). After multivariable logistic regression, we identified BADLI and Charlson index as independent predictors for 6-months mortality [BADLI (every decrease of 10 points) OR 1.21 95% CI (1.03–1.42) and Charlson index OR 1.71 95% CI (1.21–2.43)]. Body mass index (BMI) values were inversely related to mortality [OR 0.85 95% CI (0.75–0.95)]. In conclusion, BADLI, BMI, and Charlson index scores are independent predictive factors for 6-month all-cause mortality in old patients with VTE.

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Abbreviations

VTE:

Venous thromboembolism

DVT:

Deep vein thrombosis

PE:

Pulmonary embolism

CCI:

Charlson comorbidity index

BMI:

Body mass index

BADLI:

Barthel activities of daily life index

OR:

Odds ratio

CI:

Confidence interval

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Acknowledgements

The authors of this study sincerely thank the team of junior doctors of Internal Medicine involved in our VTE group for their collaboration.

Author information

Authors and Affiliations

  1. Internal Medicine Department, Hospital Universitario 12 de Octubre, Avenida de Córdoba s/n, 28041, Madrid, Spain

    Covadonga Gómez-Cuervo, Carmen Díaz-Pedroche, María Asunción Pérez-Jacoiste Asín, Antonio Lalueza, Raquel Díaz-Simón, Francisco Trapiello, Diana Paredes & Carlos Lumbreras

  2. Pneumology Department, Hospital Universitario 12 de Octubre, Madrid, Spain

    Roberto del Pozo

Authors
  1. Covadonga Gómez-Cuervo
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  2. Carmen Díaz-Pedroche
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  3. María Asunción Pérez-Jacoiste Asín
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  4. Antonio Lalueza
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  5. Roberto del Pozo
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  6. Raquel Díaz-Simón
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Contributions

Substantial contributions to conception and design of the work: CG-C and CD-P. Substantial contributions to the acquisition, analysis, and interpretation of data for the work: CG-C, MAP-JA, AL, RdP, RD-S, FT, DP. Drafting of the work or revising it critically for important intellectual content: CG-C, CD-P and CL. All the authors approved the final version to be published.

Corresponding author

Correspondence to Covadonga Gómez-Cuervo.

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Conflict of interest

The following facts may be considered as potential conflicts of interest: Dr. Díaz-Pedroche receives funding from Leo-Pharma, Bayer, Sanofi and Aspen-Pharma for several projects, not related to the current study. Dr. Díaz-Simón collaborates with Menarini, Bayer, Sanofi and Almirall in several projects, not related to the current study. We wish to confirm that there are no other known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome.

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Gómez-Cuervo, C., Díaz-Pedroche, C., Pérez-Jacoiste Asín, M.A. et al. Impact of functional status on 6-month mortality in elderly patients with acute venous thromboembolism: results from a prospective cohort. J Thromb Thrombolysis 46, 325–331 (2018). https://doi.org/10.1007/s11239-018-1685-3

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