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Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review

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Abstract

Purpose

This umbrella review aims to evaluate the quality, summarize and compare the conclusions of systematic reviews investigating the impact of curative treatment options on health-related quality of life (HRQoL) in muscle-invasive bladder cancer (MIBC).

Methods

The Cochrane Library, MEDLINE, Embase and Web of Science were searched independently by two authors from inception until 06 January 2020. Systematic reviews and meta-analyses assessing the impact of any curative treatment option on HRQol in MIBC patients were eligible. Risk of bias was assessed using the AMSTAR 2 tool.

Results

Thirty-two reviews were included. Robot-assisted RC with extracorporeal urinary diversion and open RC have similar HRQoL (n = 10). Evidence for pelvic organ-sparing RC was too limited (n = 2). Patients with a neobladder showed better overall and physical HRQoL outcomes, but worse urinary function in comparison with ileal conduit (n = 17). Bladder-preserving radiochemotherapy showed slightly better urinary and sexual but worse gastro-intestinal HRQoL outcomes in comparison with RC patients (n = 6). Quality of the reviews was low in more than 50% of the available reviews and most of the studies included in the reviews were nonrandomized studies.

Conclusion

This umbrella review gives a comprehensive overview of the available evidence to date.

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References

  1. Witjes, J. A., Lebret, T., Compérat, E. M., Cowan, N. C., De Santis, M., Bruins, H. M., et al. (2017). Updated 2016 EAU guidelines on muscle-invasive and metastatic bladder cancer. European Urology, 71(3), 462–475.

    Article  Google Scholar 

  2. Stenzl, A., Witjes, J., Compérat, E., Cowan, N., De Santis, M., Kuczyk, M., et al. (2012). Bladder Cancer Muscle-invasive and metastatic. European Urology, 65(4), 778–792. https://doi.org/10.1016/j.eururo.2013.11.046.

    Article  Google Scholar 

  3. Van Rhijn, B. W., Burger, M., Lotan, Y., Solsona, E., Stief, C. G., Sylvester, R. J., et al. (2009). Recurrence and progression of disease in non–muscle-invasive bladder cancer: from epidemiology to treatment strategy. European Urology, 56(3), 430–442.

    Article  Google Scholar 

  4. Mahdavifar, N., Ghoncheh, M., Pakzad, R., Momenimovahed, Z., & Salehiniya, H. (2016). Epidemiology, incidence and mortality of bladder cancer and their relationship with the development index in the world. Asian Pacific Journal of Cancer Prevention, 17(1), 381–386.

    Article  Google Scholar 

  5. Galsky, M. D., Diefenbach, M., Mohamed, N., Baker, C., Pokhriya, S., Rogers, J., et al. (2017). Web-based tool to facilitate shared decision making with regard to neoadjuvant chemotherapy use in muscle-invasive bladder cancer. JCO Clinical Cancer Informatics, 1, 1–12.

    Google Scholar 

  6. Davis, R. B., Farber, N. J., Tabakin, A. L., Kim, I. Y., & Elsamra, S. E. (2016). Open versus robotic cystectomy: Comparison of outcomes. Investigative and Clinical Urology, 57(Suppl 1), S36–43. https://doi.org/10.4111/icu.2016.57.S1.S36.

    Article  Google Scholar 

  7. Hu, J. C., Gu, X., Lipsitz, S. R., Barry, M. J., D’Amico, A. V., Weinberg, A. C., et al. (2009). Comparative effectiveness of minimally invasive vs open radical prostatectomy. JAMA, 302(14), 1557–1564.

    Article  CAS  Google Scholar 

  8. Schwenk, W., Haase, O., Neudecker, J. J., & Müller, J. M. J. C. (2005). Short term benefits for laparoscopic colorectal resection. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD003145.pub2.

    Article  Google Scholar 

  9. Zaghloul, M. S., Christodouleas, J. P., Smith, A., Abdallah, A., William, H., Khaled, H. M., et al. (2018). Adjuvant sandwich chemotherapy plus radiotherapy vs adjuvant chemotherapy alone for locally advanced bladder cancer after radical cystectomy: a randomized phase 2 trial. JAMA Surgery, 153(1), e174591–e174591.

    Article  Google Scholar 

  10. Nygren, J., Ljungqvist, O., & Thorell, A. (2017). Enhanced recovery after surgery: ERAS. Surgical Patient Care (pp. 349–361). Cham: Springer.

    Chapter  Google Scholar 

  11. Kulkarni, G. S., Hermanns, T., Wei, Y., Bhindi, B., Satkunasivam, R., Athanasopoulos, P., et al. (2017). Propensity score analysis of radical cystectomy versus bladder-sparing trimodal therapy in the setting of a multidisciplinary bladder cancer clinic. Journal of Clinical Oncology, 35(20), 2299–2305.

    Article  Google Scholar 

  12. Glatzer, M., Panje, C. M., Sirén, C., Cihoric, N., & Putora, P. M. (2018). Decision making criteria in oncology. Oncology, 98(6), 39–47.

    Google Scholar 

  13. Berry, D. L., Nayak, M., Halpenny, B., Harrington, S., Loughlin, K. R., Chang, P., et al. (2015). Treatment decision making in patients with bladder cancer. Bladder Cancer, 1(2), 151–158. https://doi.org/10.3233/blc-150029.

    Article  Google Scholar 

  14. Mohamed, N. E., Gilbert, F., Lee, C. T., Sfakianos, J., Knauer, C., Mehrazin, R., et al. (2016). Pursuing quality in the application of bladder cancer quality of life research. Bladder Cancer, 2(2), 139–149. https://doi.org/10.3233/blc-160051.

    Article  CAS  Google Scholar 

  15. Wright, J. L., & Porter, M. P. (2007). Quality-of-life assessment in patients with bladder cancer. Nat Clin Pract Urol, 4(3), 147–154. https://doi.org/10.1038/ncpuro0750.

    Article  Google Scholar 

  16. Mason, S. J., Catto, J. W., Downing, A., Bottomley, S. E., Glaser, A. W., & Wright, P. (2018). Evaluating patient-reported outcome measures (PROM s) for bladder cancer: a systematic review using the CO nsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. BJU International, 122(5), 760–773.

    Article  Google Scholar 

  17. Tamburini, M. (2001). Health-related quality of life measures in cancer. Annals of Oncology, 12(suppl_3), S7–S10.

    Article  Google Scholar 

  18. Aromataris, E., Fernandez, R., Godfrey, C. M., Holly, C., Khalil, H., & Tungpunkom, P. (2015). Summarizing systematic reviews: methodological development, conduct and reporting of an umbrella review approach. International Journal of Evidence-Based Healthcare, 13(3), 132–140.

    Article  Google Scholar 

  19. Shea, B. J., Reeves, B. C., Wells, G., Thuku, M., Hamel, C., Moran, J., et al. (2017). AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both. BMJ, 358, j4008.

    Article  Google Scholar 

  20. Botteman, M. F., Pashos, C. L., Hauser, R. S., Laskin, B. L., & Redaelli, A. (2003). Quality of life aspects of bladder cancer: A review of the literature. Quality of Life Research, 12(6), 675–688. https://doi.org/10.1023/A:1025144617752.

    Article  CAS  Google Scholar 

  21. Parkinson, J. P., & Konety, B. R. (2004). Health related quality of life assessments for patients with bladder cancer. Journal of Urology, 172(6 I), 2130–2136. https://doi.org/10.1097/01.ju.0000139445.49500.24.

    Article  Google Scholar 

  22. Gerharz, E. W., Mansson, A., Hunt, S., Skinner, E. C., & Mansson, W. (2005). Quality of life after cystectomy and urinary diversion: An evidence based analysis. Journal of Urology, 174(5), 1729–1736. https://doi.org/10.1097/01.ju.000176463.40530.05.

    Article  Google Scholar 

  23. Porter, M. P., & Penson, D. F. (2005). Health related quality of life after radical cystectomy and urinary diversion for bladder cancer: A systematic review and critical analysis of the literature. Journal of Urology, 173(4), 1318–1322. https://doi.org/10.1097/01.ju.0000149080.82697.65.

    Article  Google Scholar 

  24. Somani, B. K., Gimlin, D., Fayers, P., & N'Dow, J. (2009). Quality of life and body image for bladder cancer patients undergoing radical cystectomy and urinary diversion-A prospective cohort study with a systematic review of literature. Urology, 74(5), 1138–1143. https://doi.org/10.1016/j.urology.2009.05.087.

    Article  Google Scholar 

  25. Kassouf, W., Hautmann, R. E., Bochner, B. H., Lerner, S. P., Colombo, R., Zlotta, A., et al. (2010). A critical analysis of orthotopic bladder substitutes in adult patients with bladder cancer: Is there a perfect solution? European Urology, 58(3), 374–383. https://doi.org/10.1016/j.eururo.2010.05.023.

    Article  Google Scholar 

  26. Hautmann, R. E., Abol-Enein, H., Davidsson, T., Gudjonsson, S., Hautmann, S. H., Holm, H. V., et al. (2013). ICUD-EAU international consultation on bladder cancer 2012: Urinary diversion. European Urology, 63(1), 67–80. https://doi.org/10.1016/j.eururo.2012.08.050.

    Article  Google Scholar 

  27. Perlis, N., Krahn, M., Alibhai, S., Finelli, A., Ritvo, P., Bremner, K. E., et al. (2014). Conceptualizing global health-related quality of life in bladder cancer. Quality of Life Research: An International Journal of quality of Life Aspects of Treatment, Care and Rehabilitation, 23(8), 2153–2167. https://doi.org/10.1007/s11136-014-0685-9.

    Article  Google Scholar 

  28. Ali, A. S., Hayes, M. C., Birch, B., Dudderidge, T., & Somani, B. K. (2015). Health related quality of life (HRQoL) after cystectomy: Comparison between orthotopic neobladder and ileal conduit diversion. European Journal of Surgical Oncology, 41(3), 295–299. https://doi.org/10.1016/j.ejso.2014.05.006.

    Article  CAS  Google Scholar 

  29. Cerruto, M. A., D'Elia, C., Siracusano, S., Gedeshi, X., Mariotto, A., Iafrate, M., et al. (2016). Systematic review and meta-analysis of non RCT's on health related quality of life after radical cystectomy using validated questionnaires: Better results with orthotopic neobladder versus ileal conduit. European Journal of Surgical Oncology, 42(3), 343–360. https://doi.org/10.1016/j.ejso.2015.10.001.

    Article  CAS  Google Scholar 

  30. Crozier, J., Hennessey, D., Sengupta, S., Bolton, D., & Lawrentschuk, N. (2016). A Systematic review of ileal conduit and neobladder outcomes in primary bladder cancer. Urology, 96, 74–79. https://doi.org/10.1016/j.urology.2016.06.034.

    Article  Google Scholar 

  31. Ghosh, A., & Somani, B. (2016). Recent trends in post-cystectomy health-related quality of life (QOL) favours neobladder diversion: Systematic review of the literature. Journal of Urology, 195(4), e751.

    Google Scholar 

  32. Yang, L. S., Shan, B. L., Shan, L. L., Chin, P., Murray, S., Ahmadi, N., et al. (2016). A systematic review and meta-analysis of quality of life outcomes after radical cystectomy for bladder cancer. Surgical Oncology, 25(3), 281–297. https://doi.org/10.1016/j.suronc.2016.05.027.

    Article  Google Scholar 

  33. Cerruto, M. A., D'Elia, C., Siracusano, S., Porcaro, A. B., Cacciamani, G., De Marchi, D., et al. (2017). Is health-related quality of life after radical cystectomy using validated questionnaires really better in patients with ileal orthotopic neobladder compared to ileal conduit: A meta-analysis of retrospective comparative studies. Current Urology, 10(2), 57–68. https://doi.org/10.1159/000447153.

    Article  Google Scholar 

  34. Smith, A. B., Crowell, K., Woods, M. E., Wallen, E. M., Pruthi, R. S., Nielsen, M. E., et al. (2017). Functional outcomes following radical cystectomy in women with bladder cancer: A systematic review. European Urology Focus, 3(1), 136–143. https://doi.org/10.1016/j.euf.2016.05.005.

    Article  Google Scholar 

  35. Zahran, M. H., Fahmy, O., Ei-Hefnawy, A. S., & Ali-El-Dein, B. (2016). Female sexual dysfunction post radical cystectomy and urinary diversion. Climacteric, 19(6), 546–550. https://doi.org/10.1080/13697137.2016.1225714.

    Article  CAS  Google Scholar 

  36. Veskimae, E., Neuzillet, Y., Rouanne, M., MacLennan, S., Lam, T. B. L., Yuan, Y. H., et al. (2017). Systematic review of the oncological and functional outcomes of pelvic organ-preserving radical cystectomy (RC) compared with standard RC in women who undergo curative surgery and orthotopic neobladder substitution for bladder cancer. BJU International, 120(1), 12–24. https://doi.org/10.1111/bju.13819.

    Article  Google Scholar 

  37. Orvieto, M. A., DeCastro, G. J., Trinh, Q. D., Jeldres, C., Katz, M. H., Patel, V. R., et al. (2011). Oncological and functional outcomes after robot-assisted radical cystectomy: Critical review of current status. Urology, 78(5), 977–984. https://doi.org/10.1016/j.urology.2011.04.073.

    Article  Google Scholar 

  38. Al-Tartir, T., Raza, S., Alotaibi, M., Khan, A., Hara, I., Fujisawa, M., et al. (2015). Robot-assisted surgical approach to bladder cancer: A decade of progress! Minerva Urologica E Nefrologica, 67(1), 55–63.

    CAS  Google Scholar 

  39. Wilson, T. G., Guru, K., Rosen, R. C., Wiklund, P., Annerstedt, M., Bochner, B. H., et al. (2015). Best practices in robot-assisted radical cystectomy and urinary reconstruction: Recommendations of the pasadena consensus panel. European Urology, 67(3), 363–375. https://doi.org/10.1016/j.eururo.2014.12.009.

    Article  Google Scholar 

  40. Tan, W. S., Khetrapal, P., Tan, W. P., Rodney, S., Chau, M., & Kelly, J. D. (2016). Robotic assisted radical cystectomy with extracorporeal urinary diversion does not show a benefit over open radical cystectomy: A systematic review and meta-analysis of randomised controlled trials. PLoS ONE. https://doi.org/10.1371/journal.pone.0166221.

    Article  Google Scholar 

  41. Attalla, K., Kent, M., Waingankar, N., & Mehrazin, R. (2017). Robotic-assisted radical cystectomy versus open radical cystectomy for management of bladder cancer: Review of literature and randomized trials. Future Oncol, 13(13), 1195–1204. https://doi.org/10.2217/fon-2017-0004.

    Article  CAS  Google Scholar 

  42. Lauridsen, S. V., Tonnesen, H., Jensen, B. T., Neuner, B., Thind, P., & Thomsen, T. (2017). Complications and health-related quality of life after robot-assisted versus open radical cystectomy: A systematic review and meta-analysis of four RCTs. Syst Rev, 6(1), 150. https://doi.org/10.1186/s13643-017-0547-y.

    Article  Google Scholar 

  43. Lobo, N., Thurairaja, R., Nair, R., Dasgupta, P., & Khan, M. S. (2018). Robot-assisted radical cystectomy with intracorporeal urinary diversion—The new 'gold standard'? Evidence from a systematic review. Arab J Urol, 16(3), 307–313. https://doi.org/10.1016/j.aju.2018.01.006.

    Article  Google Scholar 

  44. Rai, B. P., Bondad, J., Vasdev, N., Adshead, J., Lane, T., Ahmed, K., et al. (2019). Robotic versus open radical cystectomy for bladder cancer in adults. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD011903.pub2.

    Article  Google Scholar 

  45. Kimura, S., Iwata, T., Foerster, B., Fossati, N., Briganti, A., Nasu, Y., et al. (2019). Comparison of perioperative complications and health-related quality of life between robot-assisted and open radical cystectomy: A systematic review and meta-analysis. International Journal of Urology, 26(8), 760–774.

    Article  Google Scholar 

  46. Sathianathen, N. J., Kalapara, A., Frydenberg, M., Lawrentschuk, N., Weight, C. J., Parekh, D., et al. (2018). Robotic-assisted radical cystectomy vs open radical cystectomy: systematic review and meta-analysis. The Journal of Urology, 201(4), 715–720.

    Article  Google Scholar 

  47. Perlis, N., Krahn, M., Alibhai, S., Finelli, A., Ritvo, P., Bremner, K. E., et al. (2014). Conceptualizing global health-related quality of life in bladder cancer. Quality of Life Research, 23(8), 2153–2167. https://doi.org/10.1007/s11136-014-0685-9.

    Article  Google Scholar 

  48. Ploussard, G., Daneshmand, S., Efstathiou, J. A., Herr, H. W., James, N. D., Rodel, C. M., et al. (2014). Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: A systematic review. European Urology, 66(1), 120–137. https://doi.org/10.1016/j.eururo.2014.02.038.

    Article  CAS  Google Scholar 

  49. Feuerstein, M. A., & Goenka, A. (2015). Quality of life outcomes for bladder cancer patients undergoing bladder preservation with radiotherapy. Current Urology Reports, 16(11), 75. https://doi.org/10.1007/s11934-015-0547-1.

    Article  Google Scholar 

  50. Taarnhoj, G. A., Johansen, C., & Pappot, H. (2019). Quality of life in bladder cancer patients receiving medical oncological treatment; a systematic review of the literature. Health Qual Life Outcomes, 17(1), 20. https://doi.org/10.1186/s12955-018-1077-6.

    Article  CAS  Google Scholar 

  51. Shi, H., Yu, H., Bellmunt, J., Leow, J. J., Chen, X., Guo, C., et al. (2018). Comparison of health-related quality of life (HRQoL) between ileal conduit diversion and orthotopic neobladder based on validated questionnaires: a systematic review and meta-analysis. Quality of Life Research, 27(11), 2759–2775. https://doi.org/10.1007/s11136-018-1902-8.

    Article  Google Scholar 

  52. Ziouziou, I., Irani, J., Wei, J. T., Karmouni, T., El Khader, K., Koutani, A., et al. (2018). Ileal conduit vs orthotopic neobladder: Which one offers the best health-related quality of life in patients undergoing radical cystectomy? A systematic review of literature and meta-analysis. Progres en Urologie, 28(5), 241–250. https://doi.org/10.1016/j.purol.2018.02.001.

    Article  CAS  Google Scholar 

  53. Somani, B. K., MacLennan, S. J., & N'Dow, J. (2010). Quality of life with urinary diversion. European Urology, Supplements, 9(10), 763–771. https://doi.org/10.1016/j.eursup.2010.09.002.

    Article  Google Scholar 

  54. Yang, L. S., Shan, B. L., Shan, L. L., Chin, P., Murray, S., Ahmadi, N., et al. (2016). A systematic review and meta-analysis of quality of life outcomes after radical cystectomy for bladder cancer. Surgical Oncology-Oxford, 25(3), 281–297. https://doi.org/10.1016/j.suronc.2016.05.027.

    Article  Google Scholar 

  55. Desai, M. M., & Gill, I. S. J. E. U. (2015). The devil is in the details": Randomized trial of robotic versus open radical cystectomy. European Urology, 67(6), 1053–1055.

    Article  Google Scholar 

  56. Catto, J. W., Khetrapal, P., Ambler, G., Sarpong, R., Khan, M. S., Tan, M., et al. (2018). Robot-assisted radical cystectomy with intracorporeal urinary diversion versus open radical cystectomy (iROC): Protocol for a randomised controlled trial with internal feasibility study. British Medical Journal Open, 8(8), e020500.

    Google Scholar 

  57. Kretschmer, A., Grimm, T., Buchner, A., Stief, C. G., & Karl, A. (2016). Prognostic features for quality of life after radical cystectomy and orthotopic neobladder. International Brazilian Journal of Urology: Official Journal of the Brazilian Society of Urology, 42(6), 1109–1120. https://doi.org/10.1590/S1677-5538.IBJU.2015.0491.

    Article  Google Scholar 

  58. Zhang, S., Yu, Y. H., Zhang, Y., Qu, W., & Li, J. (2015). Radiotherapy in muscle-invasive bladder cancer: The latest research progress and clinical application. American Journal of Cancer Research, 5(2), 854–868.

    CAS  Google Scholar 

  59. Singer, S., Ziegler, C., Schwalenberg, T., Hinz, A., Gotze, H., & Schulte, T. (2013). Quality of life in patients with muscle invasive and non-muscle invasive bladder cancer. Supportive Care in Cancer, 21(5), 1383–1393. https://doi.org/10.1007/s00520-012-1680-8.

    Article  CAS  Google Scholar 

  60. Van Hemelrijck, M., Sparano, F., Josephs, D., Sprangers, M., Cottone, F., & Efficace, F. (2019). Patient-reported outcomes in randomised clinical trials of bladder cancer: An updated systematic review. BMC Urology, 19(1), 86.

    Article  Google Scholar 

  61. Boormans, J. L., & Zwarthoff, E. C. J. B. C. (2016). Limited funds for bladder cancer research and what can we do about it. Bladder Cancer, 2(1), 49–51.

    Article  Google Scholar 

  62. Aluwini, S., Liem, E., Boormans, J., Antonisse, I., Praag, J. O., Kirkels, W., et al. (2015). Long-term treatment outcome of local recurrences after bladder preservation with brachytherapy for bladder carcinoma. International Journal of Radiation Oncology Biology Physics, 93(3), E216–E217.

    Article  Google Scholar 

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Funding

This study was funded by Kom op tegen Kanker.

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Authors and Affiliations

  1. Department of Human Structure and Repair, Ghent University, Corneel Heymanslaan 10, 9000, Ghent, Belgium

    Elke Rammant, Renée Bultijnck, Piet Ost & Thomas Van Vaerenbergh

  2. Department of Public Health and Primary Care, University Hospital, Ghent University, Ghent, Belgium

    Lisa Van Wilder

  3. School of Cancer and Pharmaceutical Studies, Translational Oncology & Urology Research (TOUR), King’s College London, London, UK

    Mieke Van Hemelrijck

  4. The Knowledge Center for Health Ghent, Ghent University, Ghent, Belgium

    Nele S. Pauwels

  5. Department of Urology, Ghent University Hospital, Ghent, Belgium

    Karel Decaestecker & Charles Van Praet

  6. Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium

    Piet Ost & Valérie Fonteyne

  7. Department of Public Health and Primary Care, University Centre for Nursing and Midwifery, Ghent University, Ghent, Belgium

    Sofie Verhaeghe & Ann Van Hecke

  8. Department of Nursing, VIVES University College, Roeselare, Belgium

    Sofie Verhaeghe

  9. Staff Member Nursing Department, Ghent University Hospital, Ghent, Belgium

    Sofie Verhaeghe & Ann Van Hecke

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Rammant, E., Van Wilder, L., Van Hemelrijck, M. et al. Health-related quality of life overview after different curative treatment options in muscle-invasive bladder cancer: an umbrella review. Qual Life Res 29, 2887–2910 (2020). https://doi.org/10.1007/s11136-020-02544-z

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