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Enhancement of the Cytotoxic Effect of Doxorubicin on Tumor Cells Upon Exposure to Atmospheric Cold Plasma

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Pharmaceutical Chemistry Journal Aims and scope

The possibility of enhancing the cytotoxic effect of doxorubicin on tumor cells with the aid of additional exposure to atmospheric cold plasma is considered. Experiments conducted in vitro on HeLa cell culture showed a 40% increase in effectiveness of doxorubicin in this combined treatment. The observed increase in the antitumor drug activity is explained by the presence of free radicals formed by plasma that produce additional genotoxic and DNA-damaging effects.

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Acknowledgments

The work was financially supported by the Russian Foundation for Basic Research (Grant No. 19-02-00378 A).

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Authors and Affiliations

  1. Pirogov Russian National Research Medical University, 1 Ostrovityanova St, Moscow, 117997, Russia

    A. G. Akopdzhanov, E. D. Sveshnikova, N. G. Guseyn-zade, L. V. Kolik, E. M. Konchekov & N. L. Shimanovskiy

  2. Prokhorov General Physics Institute, Russian Academy of Sciences, 38 Vavilova St, Moscow GSP-1, 119991, Russia

    N. G. Guseyn-zade, L. V. Kolik & E. M. Konchekov

Authors
  1. A. G. Akopdzhanov
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  2. E. D. Sveshnikova
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  3. N. G. Guseyn-zade
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  4. L. V. Kolik
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  5. E. M. Konchekov
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  6. N. L. Shimanovskiy
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Corresponding author

Correspondence to A. G. Akopdzhanov.

Additional information

Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 55, No. 1, pp. 13 – 15, January, 2021.

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Akopdzhanov, A.G., Sveshnikova, E.D., Guseyn-zade, N.G. et al. Enhancement of the Cytotoxic Effect of Doxorubicin on Tumor Cells Upon Exposure to Atmospheric Cold Plasma. Pharm Chem J 55, 11–13 (2021). https://doi.org/10.1007/s11094-021-02363-7

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  • DOI: https://doi.org/10.1007/s11094-021-02363-7

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