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Tenoxicam Modulates Antioxidant Redox System and Lipid Peroxidation in Rat Brain

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Abstract

We investigated effects of two doses of Tenoxicam, a type 2 cyclooxygenase inhibitor, administration on lipid peroxidation and antioxidant redox system in cortex of the brain in rats. Twenty-two male Wistar rats were randomly divided into three groups. First group was used as control. 10 and 20 mg/kg body weight Tenoxicam were intramuscularly administrated to rats constituting the second and third groups for 10 days, respectively. Both dose of Tenoxicam administration resulted in significant increase in the glutathione peroxidase activity, reduced glutathione and vitamins C and E of cortex of the brain. The lipid peroxidation levels in the cortex of the brain were significantly decreased by the administration. Vitamin A and β-carotene concentration was not affected by the administration. There was no statistical difference in all values between 10 and 20 mg Tenoxicam administrated groups. In conclusion, treatment of brain with 10 and 20 mg Tenoxicam has protective effects on the oxidative stress by inhibiting free radical and supporting antioxidant redox system.

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Abbreviations

GSH-Px:

Glutathione peroxidase

GSH:

Glutathione

LP:

Lipid peroxidation

MDA:

Malondialdehyde

PUFAs:

Polyunsaturated fatty acids

ROS:

Reactive oxygen species

SOD:

Superoxide dismutase

NSAIDs:

Non-steroidal anti-inflammatory drugs

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Acknowledgement

Authors wish to thank Ömer Çelik for excellent help on the analysis of antioxidant parameters.

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Authors and Affiliations

  1. Department of Biophysics, Medical (TIP) Faculty, Süleyman Demirel University, Cunur, Isparta, 32260, Turkey

    Mustafa Nazıroğlu & Abdulhadi Cihangir Uğuz

  2. Department of Histology and Embryology, Medical Faculty, Suleyman Demirel University, Isparta, Turkey

    Alpaslan Gokçimen & Dilek Ulusoy Karatopuk

  3. Department of Chemistry, Science Faculty, Dumlupınar University, Kütahya, Turkey

    Metin Bülbül

  4. Department of Cardiology, Gülkent State Hospital, Isparta, Turkey

    Yasin Türker

  5. Department of General Surgery, Suleyman Demirel University, Isparta, Turkey

    Celal Çerçi

Authors
  1. Mustafa Nazıroğlu
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  2. Abdulhadi Cihangir Uğuz
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  3. Alpaslan Gokçimen
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  4. Metin Bülbül
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Correspondence to Mustafa Nazıroğlu.

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Nazıroğlu, M., Uğuz, A.C., Gokçimen, A. et al. Tenoxicam Modulates Antioxidant Redox System and Lipid Peroxidation in Rat Brain. Neurochem Res 33, 1832–1837 (2008). https://doi.org/10.1007/s11064-008-9643-7

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  • DOI: https://doi.org/10.1007/s11064-008-9643-7

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