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Antifungal Susceptibility Profile of Candida Albicans Isolated from Vulvovaginal Candidiasis in Xinjiang Province of China

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Abstract

We investigated the antifungal susceptibility profiles of 207 independent Candida albicans strains isolated from patients with vulvovaginal candidiasis (VVC) in Xinjiang Province of China. Using CLSI M27-A3 and M27-S4 guidelines, anidulafungin and micafungin were the most active drugs against C. albicans showing an MIC50/MIC90 corresponding to 0.016/0.0313 µg/mL, followed by caspofungin (0.25/0.25 µg/mL), posaconazole (0.125/0.5 µg/mL), ravuconazole (0.063/1 µg/mL), itraconazole (0.125/1 µg/mL), amphotericine B (0.5/1 µg/mL), isavuconazole (0.063/2 µg/mL), 5-flucytosine (1/2 µg/mL), voriconazole (0.125/4 µg/mL), and fluconazole (0.5/4 µg/mL). 96.1% (199)–100.0% (207) isolates were sensitive to the three echinocandins tested, amphotericine B and 5-flucytosine. The in vitro activity of triazoles against all isolates tested was variable; itraconazole and voriconazole had reduced the activity to almost half of the isolates (55.1% (114) and 51.2% (106) susceptible, respectively). Fluconazole was active against 76.3% (158) isolates tested. The new triazoles ravuconazole, isavuconazole and posaconazole showed good in vitro potency against 89.9% (186)–95.2% (197) of isolates with the geometric mean MIC (µg/mL) of 0.10, 0.12 and 0.14 µg/mL, respectively. In conclusion, our study indicates that for effective management of systemic candidiasis in Xinjiang Province of China, it is important to determine the susceptibility profiles of isolated C. albicans from patients with VVC.

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Acknowledgements

This study was supported by Suzhou New & Hi-Tech IDZ grant 2017Z008, in part by Shanghai Science Foundation of China under Grant 16DZ0500401. Seyedmojtaba Seyedmousavi is presently supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.

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  1. Liang Yan and Xiao-dong Wang have contributed equally to this work.

Authors and Affiliations

  1. The People’s Hospital of Suzhou National New & Hi-Tech Industrial Development Zone, Suzhou, Jiangsu, China

    Nong Yu & Shu-wen Deng

  2. Shanghai Key Laboratory of Medical Molecular Mycology & PLA Key Laboratory of Fungal Disease, Department of Dermatology, Changzheng Hospital, Second Military Medical University, Shanghai, China

    Liang Yan, Juan-na Yuan, Wei-hua Pan, Ya-li Yang & Wan-qing Liao

  3. Wuhan General Hospital of Chinese PLA, Wuhan, Hubei, China

    Liang Yan

  4. The First Affiliated Hospital of Xinjiang Medical University, Ürümqi, Xinjiang, China

    Xiao-dong Wang & Palida Abulize

  5. Molecular Microbiology Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA

    Seyedmojtaba Seyedmousavi

  6. Center of Expertise in Microbiology, Infection Biology and Antimicrobial Pharmacology, Tehran, Iran

    Seyedmojtaba Seyedmousavi

  7. Invasive Fungi Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Seyedmojtaba Seyedmousavi

  8. The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong, China

    Juan-na Yuan

  9. Department of Laboratory Medicine, Changzheng Hospital, Second Military Medical University, Shanghai, China

    Hai-qing Hu

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  1. Liang Yan
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Yan, L., Wang, Xd., Seyedmousavi, S. et al. Antifungal Susceptibility Profile of Candida Albicans Isolated from Vulvovaginal Candidiasis in Xinjiang Province of China. Mycopathologia 184, 413–422 (2019). https://doi.org/10.1007/s11046-018-0305-2

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