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Simultaneous Positivity for Anti-DNA, Anti-Nucleosome and Anti-Histone Antibodies is a Marker for More Severe Lupus Nephritis

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Journal of Clinical Immunology Aims and scope Submit manuscript

An Erratum to this article was published on 16 December 2012

Abstract

Objective

The purpose of this study is to examine autoantibody profile of systemic lupus erythematosus (SLE) patients with lupus nephritis (LN) and to establish the correlation between the antibody reactivity and disease activity of LN.

Methods

Autoantibodies and serological parameters were measured and analyzed in 589 SLE patients. The associations of the co-positivity of anti-dsDNA, -nucleosome and –histone antibodies (3-pos) with clinical, serological and outcome parameters were analyzed.

Results

At the study entry, the prevalence for anti-dsDNA (61.52 % vs. 34.11 %, P < 0.0001), anti-nucleosome (56.09 % vs. 37.21 %, P = 0.0002) and anti-histone (49.35 % vs. 33.33 %, P = 0.0013) antibodies in patients with LN were significantly higher than that in patients without LN. Patients with 3-pos had a higher proportion of proliferative renal lesions (class III + IV). The incidence of a poor renal outcome (7.14 % vs. 2.52 %, P = 0.0174) in LN patients with 3-pos was significantly higher than those without 3-pos. Moreover, the rate of remission (73.63 % vs. 82.37 %, P = 0.0245) was significantly reduced and recurrence increased (58.90 % vs. 23.44 %, P < 0.0001) in 3-pos patients as compared to that in non 3-pos within the LN group.

Conclusion

Our data indicate a strong association between the 3-pos and renal disease activities, especially proliferative glomerulonephritis. The ability of 3-pos to predict renal flares may lead to major additional benefits in the follow-up of these patients.

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Acknowledgment

We are very grateful to Professor Jin Xiaoming and Zhao Ruibo for assistance in the scoring and collecting pathological data of the SLE patients.

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Authors and Affiliations

  1. Department of Nephrology, First Hospital Affiliated to Harbin Medical University, 150001, Harbin, China

    Mansu Sui, Xiaojing Han, Rujuan Xie & Xiaofang Guo

  2. Department of Immunology, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China

    Qingyuan Lin, Xiuzhi Jia & Huan Ren

  3. Immunity & Infection Key laboratory of Heilongjiang Province, 150081, Harbin, China

    Qingyuan Lin, Xiuzhi Jia & Huan Ren

  4. Department of Clinical Laboratory Medicine, First Hospital Affiliated to Harbin Medical University, 150001, Harbin, China

    Zhaozhen Xu & Xiuru Guan

  5. Department of Pathophysiology, Harbin Medical University, 150081, Harbin, China

    Weihua Zhang

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  1. Mansu Sui
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Correspondence to Huan Ren.

Additional information

The presented work was supported by National Science Foundation of China (Grant NFSC-30227738) and a grant from Heilongjiang Education Bureau, China (Grant 12521180). No potential conflict of interest relevant to this article was reported.

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Sui, M., Lin, Q., Xu, Z. et al. Simultaneous Positivity for Anti-DNA, Anti-Nucleosome and Anti-Histone Antibodies is a Marker for More Severe Lupus Nephritis. J Clin Immunol 33, 378–387 (2013). https://doi.org/10.1007/s10875-012-9825-6

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