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Lack of Association of VDR Gene Polymorphisms with Thyroid Autoimmune Disorders: Familial and Case/Control Studies

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Abstract

We study the association between three Vitamin D receptor gene polymorphisms (rs10735810, rs1544410, rs731236) and susceptibility to thyroid autoimmune diseases. Seventy-six affected subjects, belonging to a large family, as well as one hundred unrelated Tunisian patients and one hundred healthy Tunisian controls were genotyped. A family-based association test and a standard chi-square test were used to assess association in family and case-control data, respectively. Our results showed no significant association of the Vitamin D receptor gene polymorphisms with the susceptibility to thyroid autoimmune diseases in the family. Moreover, allele frequencies for the three polymorphisms in the Tunisian population were similar to those reported in the Tunisian control population and none was associated with the disease. These results suggest a lack of association between the Vitamin D receptor gene polymorphisms and susceptibility to thyroid autoimmune diseases in Tunisian population, in agreement with data from the UK, but in conflict with studies from the Far East.

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Acknowledgment

This work was funded by the Association Française des polyarthritiques, Association de Recherche pour la Polyarthrite, Association Polyarctique, Association Rhumatisme et Travail, Société Française de Rhumatologie, Genopole, Université d‘Evry-Val d’Essonne, Shering-Plough, Pfizer, Amgen, Conseil Régional Ile de France, Conseil Général de L’Essonne, Ministère de la Recherche et de l’enseignement supérieur, Fondation pour la Recherche Médicale (France), Ministère de l’Enseignement supérieur, Ministère de la Recherche Scientifique de la Technologie et du developpement des compétences (Tunisie) and the International Centre for Genetic Engineering and Biotechnology (ICGEB) Trieste (Italy).

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Authors and Affiliations

  1. Faculté de Médecine, Laboratoire de Génétique Moléculaire Humaine, Avenue Majida Boulila, 3029, Sfax, Tunisia

    Abdellatif Maalej, Ghazi Chabchoub, Mariam Ben Hamad & Hammadi Ayadi

  2. Genotel-EA3886 Laboratoire de Recherche Européen pour la polyarthrite Rhumatoïde, Université d’Evry-Val d’Essonne, ECRAF-Université Paris 7, 2 rue Gaston Crémieux, CP5727 91057, Evry, France

    Elisabeth Petit-Teixeira & Francois Cornelis

  3. Unité de Bioinformatique, Centre de Biotechnologie de Sfax, BP K, Sfax, Tunisia

    Ahmed Rebai

  4. Osancor Biotech Inc, Waltford, Hertfordshire, WD17 4EJ, UK

    Nadir R. Farid

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  1. Abdellatif Maalej
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  2. Elisabeth Petit-Teixeira
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  3. Ghazi Chabchoub
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  4. Mariam Ben Hamad
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Correspondence to Abdellatif Maalej.

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Maalej, A., Petit-Teixeira, E., Chabchoub, G. et al. Lack of Association of VDR Gene Polymorphisms with Thyroid Autoimmune Disorders: Familial and Case/Control Studies. J Clin Immunol 28, 21–25 (2008). https://doi.org/10.1007/s10875-007-9124-9

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  • DOI: https://doi.org/10.1007/s10875-007-9124-9

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