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Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study

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Abstract

The serotonin system has been shown to be involved in the regulation of hostility, anger, and aggressive behavior. Previous molecular genetic studies suggest that the serotonin receptor 1B (HTR1B) rs6296 genotype might have a particular role in these types of behaviors. We examined whether HTR1B is related to hostility, anger, and aggressive behavior phenotypes over a lifespan and whether it modifies the connection between childhood aggressive behavior and adulthood hostility and anger. The participants were 967 women and men from a large population based sample (The Young Finns Study) with a 27-year follow-up. Childhood aggressive behavior was reported by the mother twice when the participants were 3 to 12 years of age. Adulthood hostility and anger were self-reported by the participants between ages 24 and 36. Childhood aggressive behavior predicted adulthood hostility over 27 years. HTR1B SNP rs6296 was associated with childhood aggressive behavior but not with adulthood anger or hostility. The HTR1B SNP rs6296 modified the association between childhood aggressive behavior and adulthood hostility. Aggressive behavior and hostility might form a life course pattern, and the HTR1B might contribute to a development of this pattern.

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Acknowledgments

This study was financially supported by the Academy of Finland Grants 117797, 126925, 121584, 117941, 12362 (L.P.R.), 258711 (L.K.J.), 258578 (M.H.), the Social Insurance Institution of Finland, the Turku University Foundation, the Finnish Cultural Foundation, the Yrjö Jahnsson Foundation, the Research Foundation of the University of Helsinki (C.H.), the Emil Aaltonen Foundation (M.H. and T.L.), the Ella and Georg Ehrnrooth Foundation (M.H), the Finnish Cultural Foundation (P.M.), the Medical Research Fund of Tampere University Hospital, the Turku University Central Hospital Medical Fund, the Juho Vainio Foundation, the Finnish Foundation for Cardiovascular Research (M.H.), the Research Funds of the University of Helsinki (M.H.), the Signe and Ane Gyllenberg Foundation (L.K.J) and the Tampere Tuberculosis Foundation.

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Authors and Affiliations

  1. IBS, Unit of Personality, Work and Health Psychology, University of Helsinki, P.O. Box 9, 00014, Helsinki, Finland

    Christian Hakulinen, Markus Jokela, Mirka Hintsanen, Päivi Merjonen, Laura Pulkki-Råback & Liisa Keltikangas-Järvinen

  2. Helsinki Collegium for Advanced Studies, University of Helsinki, Helsinki, Finland

    Mirka Hintsanen

  3. Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre for Laboratory Medicine, Tampere University Hospital, Tampere, Finland

    Ilkka Seppälä, Leo-Pekka Lyytikäinen & Terho Lehtimäki

  4. Medical School, University of Tampere, Tampere, Finland

    Ilkka Seppälä, Leo-Pekka Lyytikäinen, Terho Lehtimäki & Mika Kähönen

  5. Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland

    Mika Kähönen

  6. Department of Medicine, Turku University Hospital, Turku, Finland

    Jorma Viikari

  7. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland

    Olli T. Raitakari

  8. Departments of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland

    Olli T. Raitakari

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  1. Christian Hakulinen
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Correspondence to Liisa Keltikangas-Järvinen.

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Hakulinen, C., Jokela, M., Hintsanen, M. et al. Serotonin receptor 1B genotype and hostility, anger and aggressive behavior through the lifespan: the Young Finns study. J Behav Med 36, 583–590 (2013). https://doi.org/10.1007/s10865-012-9452-y

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