Abstract
Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 ± 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 ± 4.5% and, 69.0 ± 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and ~30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.
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Acknowledgements
This research was supported by AMED under Grant Number JP18im0502004, a Grant-in-Aid for Young Researcher (B) by the Japan Society for the Promotion of Science (JSPS) grant number: JP16K20505) and the priority issues of Health Research Institute, National Institute of Advanced Industrial Science and Technology (AIST).
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Sugiura, Y., Munar, M.L. & Ishikawa, K. Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor. J Mater Sci: Mater Med 29, 151 (2018). https://doi.org/10.1007/s10856-018-6162-1
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DOI: https://doi.org/10.1007/s10856-018-6162-1