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Sacrificial functional polystyrene template to prepare chitosan nanocapsules and in vitro drug release properties

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Abstract

In this study, biocompatible and biodegradable chitosan (CS) nanocapsules are successfully prepared in abundant and easily using carboxyl-functionalized polystyrene (PS) as sacrificial template and cross-linked CS with glutaraldehyde as the shell. First, the monodisperse functionalized PS templates be about 200 nm are made by emulsifier-free emulsion polymerization. Second, nanocapsules are accomplished by fabricating on the basis of chemical cross-linking on the surface of the PS template and removing the core via tetrahydrofuran. The templates and nanocapsules were characterized by FT–IR, 1H NMR, FESEM, and TEM. All the results confirmed that the nanocapsules are accomplished via this method. By dissolution of ibuprofen in the chloroform droplets when prepare the carboxyl-functionalized PS, drug-loaded nanocapsules are also fabricated. It is found that the loaded drug can be released again in a sustained manner for up to 80 h. The nanocapsules walls have a prominent effect in slowing down the drug release rate.

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Acknowledgements

We greatly appreciate the help from Central Laboratory of Analysis and Structure Research in University of Science and Technology of China (USTC). This study is financially supported the National Science Foundation for Post-doctoral Scientists of China (no. 20100471000).

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, School of Pharmaceutical and Chemical Engineering, Taizhou University, Linhai, 317000, Zhejiang, People’s Republic of China

    Weijun Liu, Guihua Chen, Guanghong He & Zhicai He

  2. Department of Polymer Science and Engineering, Anhui University, Hefei, 230026, Anhui, People’s Republic of China

    Zhang Qian

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  1. Weijun Liu
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  2. Guihua Chen
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  3. Guanghong He
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  4. Zhicai He
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Correspondence to Weijun Liu.

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Liu, W., Chen, G., He, G. et al. Sacrificial functional polystyrene template to prepare chitosan nanocapsules and in vitro drug release properties. J Mater Sci 46, 6758–6765 (2011). https://doi.org/10.1007/s10853-011-5632-3

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  • DOI: https://doi.org/10.1007/s10853-011-5632-3

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