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Fragment-based lead discovery: challenges and opportunities

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Abstract

Fragment-based lead discovery has undergone remarkable changes over the last 15 years. During this time, the pharmaceutical industry has changed dramatically as well, and continued evolution of the industry is assured. These changes present many challenges but also several opportunities for executing fragment-based drug design. This article will explore some of the more significant changes in the industry and how they may affect future discovery efforts related to fragment-based initiatives.

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Authors and Affiliations

  1. Pharmaceutical Discovery Division, Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL, 60064-3500, USA

    Chaohong Sun, Andrew M. Petros & Philip J. Hajduk

Authors
  1. Chaohong Sun
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  2. Andrew M. Petros
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  3. Philip J. Hajduk
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Correspondence to Philip J. Hajduk.

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Sun, C., Petros, A.M. & Hajduk, P.J. Fragment-based lead discovery: challenges and opportunities. J Comput Aided Mol Des 25, 607–610 (2011). https://doi.org/10.1007/s10822-011-9451-z

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  • DOI: https://doi.org/10.1007/s10822-011-9451-z

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