Abstract
Within the field of materials science and engineering, anisotropic materials outstand for their great versatility. Their properties are different depending on the direction in which they are produced, being able to adapt better to heterogeneous behaviors, typical in almost all applications (i.e. tissue engineering or architecture), without having to pursue a compromise in the properties of the material. In this work, a comparative study was carried out involving electrospun PCL/gelatin scaffolds obtained with different alignments. A mechanical and morphological characterization was conducted in the parallel and perpendicular directions with respect to the fiber formation with the aim of analyzing the anisotropy of the samples. The random system presented an imperfect homogeneous nanostructure, which made the scaffold to be isotropic, whereas the aligned system allowed the appearance of discontinuities, giving rise to fracture points (grains) and thus inducing the breakdown of the sample.
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References
Angulo DEL, Sobral PJ do A (2016) The effect of processing parameters and solid concentration on the microstructure and pore architecture of gelatin-chitosan scaffolds produced by freeze-drying. Mater Res 19:839–845
Chortos A, Liu J, Bao Z (2016) Pursuing prosthetic electronic skin. Nat Mater 15:937
Daniel IM, Ishai O (2006) Engineering mechanics of composite materials, Second edn. Oxford University Press, New York
Doshi J, Reneker DH (1995) Electrospinning process and applications of electrospun fibers. J Electrostat 35:151–160. https://doi.org/10.1016/0304-3886(95)00041-8
Du Y, Liu H, Yang Q et al (2017) Selective laser sintering scaffold with hierarchical architecture and gradient composition for osteochondral repair in rabbits. Biomaterials 137:37–48. https://doi.org/10.1016/j.biomaterials.2017.05.021
Dunn AC, Cobb JA, Kantzios AN et al (2008) Friction coefficient measurement of hydrogel materials on living epithelial cells. Tribol Lett 30:13. https://doi.org/10.1007/s11249-008-9306-5
Engelbrecht J (2018) A feasibility study of automation in manufacturing processes among scaffold manufacturers. North-West University
Engels TAP, Govaert LE, Meijer HEH (2009) The influence of molecular orientation on the yield and post-yield response of injection-molded polycarbonate. Macromol Mater Eng 294:821–828. https://doi.org/10.1002/mame.200900050
Frenot A, Chronakis IS (2003) Polymer nanofibers assembled by electrospinning. Curr Opin Colloid Interface Sci 8:64–75. https://doi.org/10.1016/S1359-0294(03)00004-9
Gizzi A, Pandolfi A, Vasta M (2016) Statistical characterization of the anisotropic strain energy in soft materials with distributed fibers. Mech Mater 92:119–138. https://doi.org/10.1016/j.mechmat.2015.09.008
Gong J (2006) Friction and lubrication of hydrogels—its richness and complexity. Soft Matter 2:544–552. https://doi.org/10.1039/b603209p
Gurtin ME, Ian Murdoch A (1978) Surface stress in solids. Int J Solids Struct 14:431–440. https://doi.org/10.1016/0020-7683(78)90008-2
Hekmati AH, Rashidi A, Ghazisaeidi R, Drean JY (2013) Effect of needle length, electrospinning distance, and solution concentration on morphological properties of polyamide-6 electrospun nanowebs. Text Res J 83:1452–1466. https://doi.org/10.1177/0040517512471746
Jose MV, Thomas V, Dean DR, Nyairo E (2009) Fabrication and characterization of aligned nanofibrous PLGA / Collagen blends as bone tissue scaffolds. Polymer 50:3778–3785. https://doi.org/10.1016/j.polymer.2009.05.035
Kai D, Prabhakaran MP, Jin G, Ramakrishna S (2011) Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering. J Biomed Mater Res Part B Appl Biomater 98 B:379–386. https://doi.org/10.1002/jbm.b.31862
Kubiak KJ, Mathia TG (2014) Anisotropic wetting of hydrophobic and hydrophilic surfaces-modelling by Lattice Boltzmann method. Procedia Eng 79:45–48. https://doi.org/10.1016/j.proeng.2014.06.307
Lapusta Y, Wagner W (2005) Effects of fiber anisotropy on the microbuckling loads for a fiber composite. Int J Fract 131:L53–L59. https://doi.org/10.1007/s10704-005-2600-4
Law KY (2014) Definitions for hydrophilicity, hydrophobicity, and superhydrophobicity: getting the basics right. J Phys Chem Lett 5:686–688. https://doi.org/10.1021/jz402762h
Legarth BN, Tvergaard V, Kuroda M (2002) Effects of plastic anisotropy on crack-tip behaviour. Int J Fract 117:297–312. https://doi.org/10.1023/A:1022240600495
Mikata Y (2019) Linear peridynamics for isotropic and anisotropic materials. Int J Solids Struct 158:116–127. https://doi.org/10.1016/j.ijsolstr.2018.09.004
Nezarati RM, Eifert MB, Cosgriff-hernandez E (2013) Effects of humidity and solution viscosity on electrospun fiber morphology. Tissue Eng Part C 19:810–819. https://doi.org/10.1089/ten.tec.2012.0671
O’Brien FJ (2011) Biomaterials & scaffolds for tissue engineering. Mater Today 14:88–95. https://doi.org/10.1016/S1369-7021(11)70058-X
Pandey S, Rathore K, Johnson J, Cekanova M (2018) Aligned nanofiber material supports cell growth and increases osteogenesis in canine adipose-derived mesenchymal stem cells in vitro. J Biomed Mater Res A 106:1780–1788. https://doi.org/10.1002/jbm.a.36381
Perez-Puyana V, Jiménez-Rosado M, Romero A, Guerrero A (2018) Development of PVA/gelatin nanofibrous scaffolds for tissue engineering via electrospinning. Mater Res Express. https://doi.org/10.1088/2053-1591/aab164
Perez-Puyana V, Jiménez-Rosado M, Rubio-Valle JF et al (2019) Gelatin vs collagen-based sponges: evaluation of concentration, additives and biocomposites. J Polym Res 26:190. https://doi.org/10.1007/s10965-019-1863-9
Putignano C (2020) Soft lubrication: a generalized numerical methodology. J Mech Phys Solids 134:103748. https://doi.org/10.1016/j.jmps.2019.103748
Putignano C, Menga N, Afferrante L, Carbone G (2019) Viscoelastic induced anisotropy in contact mechanics of rough solids. J Mech Phys Solids. https://doi.org/10.1016/j.jmps.2019.03.024
Rogers TG (1989) Rheological characterization of anisotropic materials. Composites 20:21–27. https://doi.org/10.1016/0010-4361(89)90677-0
Selway N, Chan V, Stokes JR (2017) Influence of fluid viscosity and wetting on multiscale viscoelastic lubrication in soft tribological contacts. Soft Matter 13:1702–1715. https://doi.org/10.1039/C6SM02417C
Suzuki Y, Miwa S (2019) Magnetic anisotropy of ferromagnetic metals in low-symmetry systems. Phys Lett A 383:1203–1206. https://doi.org/10.1016/j.physleta.2019.01.020
Wang J, Huang Z, Duan H et al (2011) Surface stress effect in mechanics of nanostructured materials. Acta Mech Solid Sin 24:52–82. https://doi.org/10.1016/S0894-9166(11)60009-8
Wang Z, Chen E, Zhao Y (2018) The effect of surface anisotropy on contact angles and the characterization of elliptical cap droplets. Sci China Technol Sci 61:309–316. https://doi.org/10.1007/s11431-017-9149-1
Wisnom MR, Green D (1995) Tensile failure due to interaction between fibre breaks. Composites 26:499–508. https://doi.org/10.1016/0010-4361(95)96807-I
Wu X, Liu Y, Li X et al (2010) Preparation of aligned porous gelatin scaffolds by unidirectional freeze-drying method. Acta Biomater 6:1167–1177. https://doi.org/10.1016/j.actbio.2009.08.041
Acknowledgements
The authors gratefully acknowledge the financial support from the “Ministerio de Economía y Competitividad” (MINECO/FEDER, EU) of the Spanish Government with the research project RTI2018-097100-B-C21. The authors also acknowledge for the predoctoral fellowships of Victor M. Perez-Puyana (University of Seville, VPPI-US) and Mercedes Jiménez-Rosado (FPU17/01718-MEFP).
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Perez-Puyana, V., Jiménez-Rosado, M., Guerrero, A. et al. Anisotropic properties of PCL/gelatin scaffolds obtained via electrospinning. Int J Fract 224, 269–276 (2020). https://doi.org/10.1007/s10704-020-00460-4
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DOI: https://doi.org/10.1007/s10704-020-00460-4