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Extractable bone morphogenetic protein and correlation with induced new bone formation in an in vivo assay in the athymic mouse model

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A correlation between extractable bone morphogenetic proteins (BMPs) in demineralized bone matrix (DBM) and osteoinduction has been suggested. Extractable BMP-4 and osteoinductivity of DBM from 40 donors were assessed using enzyme-linked immunosorbent assay (ELISA) and in vivo athymic mouse assay, respectively. Extractable BMP-4 level averaged 3.7 ± 0.21 ng/g of DBM and correlated with osteoinductivity of the DBM in an in vivo assessment of induced newbone formation.

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  1. LifeNet, 5809 Ward Court, 23455, Virginia Beach, VA, USA

    Sittisak Honsawek, Ralph M. Powers & Lloyd Wolfinbarger

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  1. Sittisak Honsawek
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  2. Ralph M. Powers
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  3. Lloyd Wolfinbarger
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Correspondence to Lloyd Wolfinbarger.

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Presented in part at the Orthopaedic Research Society 49th Annual Meeting, New Orleans, Louisiana, USA, Febuary 2–5, 2003. The authors have no conflict of interest.

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Honsawek, S., Powers, R.M. & Wolfinbarger, L. Extractable bone morphogenetic protein and correlation with induced new bone formation in an in vivo assay in the athymic mouse model. Cell Tissue Banking 6, 13–23 (2005). https://doi.org/10.1007/s10561-005-1445-4

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  • DOI: https://doi.org/10.1007/s10561-005-1445-4

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