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Angiogenesis is a Link Between Atherosclerosis and Tumorigenesis: Role of LOX-1

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Abstract

Angiogenesis is defined as the formation of new blood vessels sprouting from pre-existing vessels. It plays an important role not only in physiological situations such as embryonic vascular development and wound healing, but also in pathological conditions including atherogenesis and evolution and spread of certain tumors. Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a receptor for oxidized low density lipoprotein (ox-LDL), is mainly expressed in endothelial cells. It has diverse physiological functions and it could be a link between atherogenesis and tumorigenesis. The risk factors for atherosclerosis like hypertension, diabetes mellitus and hyperlipidemia are associated with LOX-1. Dyslipidemia and obesity are also being recognized as risk factor for certain tumors. LOX-1 is also found to be important for maintaining the transformed state in developmentally diverse cancer cell lines and for tumor growth. There is emerging evidence that LOX-1 plays an important role in the angiogenesis process. In this review, we outline the roles of angiogenesis in atherogenesis and tumorigenesis, and describe the role of LOX-1 as a potential molecular target for blocking angiogenesis.

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Acknowledgments

This work was supported by Specialized Research Fund for the Doctoral Program of Higher Education, Ministry of Education of China (No. 20100162110058 to CPH), the Department of Veterans Affairs, Washington, DC, USA (JLM) and the Arkansas Bioventures Institute, Little Rock, AR, USA (JLM).

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  1. Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, 410078, China

    Junlin Jiang, Meiling Yan & Changping Hu

  2. Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences and the Central Arkansas Veterans Healthcare System, Little Rock, AR, USA

    Jawahar L. Mehta

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  1. Junlin Jiang
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Correspondence to Changping Hu.

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Jiang, J., Yan, M., Mehta, J.L. et al. Angiogenesis is a Link Between Atherosclerosis and Tumorigenesis: Role of LOX-1. Cardiovasc Drugs Ther 25, 461–468 (2011). https://doi.org/10.1007/s10557-011-6343-3

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