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Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan

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Summary

Apolipoprotein E (APOE) polymorphism plays an important role in lipid metabolism. Preliminary evidence suggests that APOE genotype appears to be a risk factor for not only cardiovascular disease, but also Alzheimer’s disease and cancer. We screened the APOE genotype in 290 breast cancer patients and 232 non-cancer controls and determined the relationship between APOE gene polymorphism and breast cancer in Taiwan. We found risk for breast cancer was associated with the APOE genotype (ξ2 = 8.652, p = 0.013). Carriers of the ε4 allele were more common in breast cancer cases than carriers of ε3 allele (p = 0.004, OR = 1.786, 95% CI: 1.197–2.664). In addition, the ε4 allele is also associated with HER2/neu negative status in breast cancer patients (p = 0.006, OR = 0.277, 95% CI: 0.111–0.693). No significant associations between APOE genotype and tumor grade, TN classification, progesterone receptor, estrogen receptor, lymphatic invasion, or recurrence of breast cancer were in evidence. These results suggest that the APOE ε4 allele may be a risk factor for breast cancer and correlates with HER2/neu negative status.

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Authors and Affiliations

  1. Department of Biochemistry, College of Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung, 404, Taiwan

    Nai-Wen Chang & Ming-Feng Wei

  2. Department of Surgery, Changhua Christian Hospital, Taiwan

    Dar-Ren Chen

  3. Department of Health, Executive Yuan, Feng-Yuan Hospital, Taiwan

    Chen-Ten Wu

  4. Department of Physiological Nursing, University of California, San Francisco, CA, USA

    Bradley E. Aouizerat

  5. Department of Social Medicine, China Medical University, Taiwan

    Fei-Na Chen

  6. Department of surgery, China Medical University Hospital, Taiwan

    Shin-Jer Hung

  7. Chinese Blood Services Foundation Taichung Blood Center, Taichung, Taiwan

    Shiuan-Huei Wang

  8. Department of Medical Oncology, Changhua Christian Hospital, Taiwan

    Cheng-Shyong Chang

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  1. Nai-Wen Chang
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  2. Dar-Ren Chen
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  9. Cheng-Shyong Chang
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Correspondence to Nai-Wen Chang.

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Chang, NW., Chen, DR., Wu, CT. et al. Influences of apolipoprotein E polymorphism on the risk for breast cancer and HER2/neu status in Taiwan. Breast Cancer Res Treat 90, 257–261 (2005). https://doi.org/10.1007/s10549-004-4656-7

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