Abstract
Despite the tremendous development of various brain-related resources, a large, systematic, comprehensive, extendable, and beautiful repository of 3D reconstructed images of a living human brain expanded to the head and neck is not yet available. I have created such a novel repository and populated it with images derived from a 3D atlas constructed from 3/7 Tesla MRI and high-resolution CT scans. This web-based repository contains 6 galleries hierarchically organized in 444 albums and sub-albums with 5,156 images. Its original features include a systematic design in terms of multiple standard views, modes of presentation, and spatially co-registered image sequences; multi-tissue class galleries constructed from 26 primary tissue classes and 199 sub-classes; and a unique image naming syntax enabling image searching based solely on the image name. Anatomic structures are displayed in 6 standard views (anterior, left, posterior, right, superior, inferior), all views having the same brain size, and optionally with additional arbitrary views. In each view, the images are shown as sequences in three standard modes of presentation, non-parcellated unlabeled, parcellated unlabeled, and parcellated labeled. There are two types of spatially co-registered image sequences (imitating image layers and enabling animation creation), the appearance image sequence (for standard views) and the context image sequence (with a growing number of tissue classes). Color-coded neuroanatomic content makes the brain beautiful and facilitates its learning and understanding. This unique repository is freely available and easily accessible online at www.nowinbrain.org for a wide spectrum of users in medicine and beyond. Its future extensions are in progress.
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Code Availability
The complete NOWinBRAIN repository with all 5,156 images along with additional materials is available publically online at www.nowinbrain.org.
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References
Amunts K, Lepage C, Borgeat L, Mohlberg H, Dickscheid T, Rousseau MÉ, … Evans, AC. (2013). Bigbrain: An ultrahigh-resolution 3D human brain model. Science:340(6139);1472–1475.
Amunts K, Ebell C, Muller J, Telefont M, Knoll A, Lippert T. (2016). The Human Brain Project: creating a European research infrastructure to decode the human brain. Neuron;92(3):574-581.
Assaf Y, Alexander DC, Jones DK, et al. (2013). The CONNECT project: Combining macro- and micro-structure. Neuroimage;80:273-82.
BRAIN Working Group. (2014). BRAIN 2025. A Scientific Vision. NIH; https://www.braininitiative.nih.gov/pdf/BRAIN2025_508C.pdf
Brodmann K. (1909). Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues. Leipzig: Barth JA.
Dickie DA, Job DE, Poole I, Ahearn TS, Staff RT, Murray AD, Wardlaw JM. (2012). Do brain image databanks support understanding of normal ageing brain structure? A systematic review. Eur Radiol.;22(7):1385-94. DOI: https://doi.org/10.1007/s00330-012-2392-7.
Fantaneanu TA, Moreau K, Eady K, Clarkin C, DeMeulemeester C, Maclean H, Doja A. (2014). Neurophobia inception: A study of trainees’ perceptions of neurology education. Can J Neurol Sci 41:421–429.
FCAT (Federative Committee on Anatomical Terminology). (1999). Terminologia Anatomica. Stuttgart – New York: Thieme.
Felten DL, O'Banion MK, Maida ME. (2015). Netter’s Atlas of Neuroscience (3rd edition). Elsevier, Amsterdam.
Flanagan E, Walsh C, Tubridy N. (2007). 'Neurophobia' - attitudes of medical students and doctors in Ireland to neurological teaching. Eur J Neurol 14: 1109-12.
Gorgolewski KJ, Varoquaux G, Rivera G, Schwarz Y, Ghosh SS, Maumet C, Sochat VV, Nichols TE, Poldrack RA, Poline JB, Yarkoni T, Margulies DS. (2015). NeuroVault.org: a web-based repository for collecting and sharing unthresholded statistical maps of the human brain. Front Neuroinform.;9:8. DOI: https://doi.org/10.3389/fninf.2015.00008.
International Brain Initiative. (2020). International Brain Initiative: An innovative framework for coordinated global brain research efforts. Neuron;105(2):212-216. DOI: https://doi.org/10.1016/j.neuron.2020.01.002.
Jiang T. (2013). Brainnetome: a new -ome to understand the brain and its disorders. Neuroimage;80:263-72.
Job DE, Dickie DA, Rodriguez D, Robson A, Danso S, Pernet C, Bastin ME, Boardman JP, Murray AD, Ahearn T, Waiter GD, Staff RT, Deary IJ, Shenkin SD, Wardlaw JM. (2017). A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS). Neuroimage;144(Pt B):299-304.
Liang P, Shi L, Chen N, et al. (2015). Construction of brain atlases based on a multi-center MRI dataset of 2020 Chinese adults. Scientific Reports;5:18216. doi: https://doi.org/10.1038/srep18216.
Martin K, Bessell NJ, Scholten I. (2014). The perceived importance of anatomy and neuroanatomy in the practice of speech-language pathology. Anatomical Sciences Education;7:28-37.
McCarron MO, Stevenson M, Loftus AM, Mckeown P. (2014). Neurophobia among general practice trainees: the evidence, perceived causes and solutions. Clin Neurol Neurosurg 122: 124-128.
Murphy KP, Crush L, O'Malley E, Daly FE, Twomey M, O'tuathaigh CM, Maher MM, Cryan JF, O'Connor OJ. (2015). Medical student perceptions of radiology use in anatomy teaching. Anatomical Sciences Education;8(6):510-517.
Netter FM, Friedlaender GE. (2014). Frank H. Netter MD and a brief history of medical illustration. Clin Orthop Relat Res.;472:812–819.
Nowinski WL. (2021). Evolution of human brain atlases in terms of content, applications, functionality, and availability. Neuroinformatics;19(1):1–22; DOI: https://doi.org/10.1007/s12021-020-09481-9.
Nowinski WL. (2017). 3D atlas of the brain, head and neck in 2953 pieces. Neuroinformatics;15(4):395–400.
Nowinski WL. (2014). Visualization and interaction in the atlas of the human brain, head and neck. Machine Graphics and Vision;23(3/4):3-10.
Nowinski WL. (2012). Proposition of a new classification of the cerebral veins based on their termination. Surgical and Radiologic Anatomy;34(2):107-114.
Nowinski WL, Chua BC, Thaung TSL, Wut Yi SH. (2015a). The Human Brain, Head and Neck in 2953 Pieces. Thieme, New York; http://www.thieme.com/nowinski/
Nowinski WL, Thaung TSL, Chua BC, Wut Yi SH, Yang Y, Urbanik A. (2015b). Three-dimensional stereotactic atlas of the extracranial vasculature correlated with the intracranial vasculature, cranial nerves, skull and muscles. The Neuroradiology Journal;28(2):190-197.
Nowinski WL, Thaung TSL, Chua BC, Wut Yi SH, Ngai V, Yang Y, Chrzan R, Urbanik A. (2015c). Three-dimensional stereotactic atlas of the adult human skull correlated with the brain, cranial nerves and intracranial vasculature. Journal of Neuroscience Methods;246:65–74.
Nowinski WL, Chua BC, Wut Yi SH. (2014). 3D Atlas of Neurologic Disorders (version 1.0). Thieme, New York, 2014.
Nowinski WL, Chua BC. (2013). The Complete Human Brain (version 1.0 for iPad). AppStore/Thieme, New York.
Nowinski WL, Chua BC, Johnson A, Qian G, Poh LE, Wut Yi SH, Aminah B, Nowinska NG. (2013). Three-dimensional interactive and stereotactic atlas of head muscles and glands correlated with cranial nerves and surface and sectional neuroanatomy. Journal of Neuroscience Methods;215(1):12-18.
Nowinski WL, Chua BC, Qian GY, Nowinska NG. (2012a). The human brain in 1700 pieces: design and development of a three-dimensional, interactive and reference atlas. Journal of Neuroscience Methods;15;204(1):44–60.
Nowinski WL, Chua BC, Yang GL, Qian GY. (2012b). Three-dimensional interactive human brain atlas of white matter tracts. Neuroinformatics;10(1):33-55.
Nowinski WL, Johnson A, Chua BC, Nowinska NG. (2012c). Three-dimensional interactive and stereotactic atlas of cranial nerves and nuclei correlated with surface neuroanatomy, vasculature and magnetic resonance imaging. Journal of Neuroscience Methods;206(2):205-216.
Nowinski WL, Chua BC, Puspitasari F, Volkau I, Marchenko Y, Knopp MV. (2011). Three-dimensional reference and stereotactic atlas of human cerebrovasculature from 7 Tesla. NeuroImage;55(3):986-998.
Nowinski WL, Volkau I, Marchenko Y, A Thirunavuukarasuu, Ng TT, Runge VM. (2009a). A 3D model of the human cerebrovasculature derived from 3 tesla 3 dimensional time-of-flight magnetic resonance angiography. Neuroinformatics;7(1):23-36.
Nowinski WL, A. Thirunnavuukarasuu, Volkau I, Marchenko Y, Aminah B, Puspitasaari F, Runge VM. (2009b). A three-dimensional interactive atlas of cerebral arterial variants. Neuroinformatics;7(4):255-264.
Nowinski WL, A Thirunavuukarasuu A, Ananthasubramaniam A, Chua BC, Qian G, Nowinska NG, Marchenko Y, Volkau I. (2009c). Automatic testing and assessment of neuroanatomy using a digital brain atlas: method and development of computer- and mobile-based applications. Anatomical Sciences Education;2(5):244-52.
Nowinski WL, Thirunavuukarasuu A, Bryan RN. (2002). The Cerefy Atlas of Brain Anatomy. An Introduction to Reading Radiological Scans for Students, Teachers, and Researchers. Thieme, New York.
Pakpoor J, Handel AE, Disanto G, Davenport RJ, Giovannoni G, Ramagopalan SV. (2014). National survey of UK medical students on the perception of neurology. BMC Med Educ;14:225.
Park JS, Chung MS, Hwang SB, Lee YS, Har DH, Park HS. (2005). Visible Korean human: improved serially sectioned images of the entire body. IEEE Trans Med Imaging;24(3):352-60.
Ruisoto P, Juanes JA, Contador I, Mayoral P, Prats‐Galino A. (2012). Experimental evidence for improved neuroimaging interpretation using three‐dimensional graphic models. Anatomical Sciences Education;5(3):132-137.
Sadato N, Morita K, Kasai K, Fukushi T, Nakamura K, Nakazawa E, Okano H, Okabe S. (2019). Neuroethical issues of the Brain/MINDS Project of Japan. Neuron;101(3):385-389. doi: https://doi.org/10.1016/j.neuron.2019.01.006.
Sunkin SM, Ng L, Lau C, Dolbeare T, Gilbert TL, Thompson CL, Hawrylycz M, Dang C. (2013). Allen Brain Atlas: an integrated spatio-temporal portal for exploring the central nervous system. Nucleic Acids Res.;41(Database issue):D996-D1008.
Spitzer VM, Ackerman MJ, Scherzinger AL, Whitlock DG. (1996). The visible human male: a technical report. J. Am. Med. Inform. Assoc.;3:118–130.
Talairach J, Tournoux P. (1988). Co-Planar Stereotactic Atlas of the Human Brain. Stuttgart - New York: Thieme.
Todd EM. (1983). The Neuroanatomy of Leonardo da Vinci. Santa Barbara, CA: Capra Press.
Tremblay-Mercier J, Madjar C, Das S, Pichet Binette A, Dyke SOM, Étienne P, Lafaille-Magnan ME, Remz J, Bellec P, Louis Collins D, Natasha Rajah M, Bohbot V, Leoutsakos JM, Iturria-Medina Y, Kat J, Hoge RD, Gauthier S, Tardif CL, Mallar Chakravarty M, Poline JB, Rosa-Neto P, Evans AC, Villeneuve S, Poirier J, Breitner JCS; PREVENT-AD Research Group. (2021). Open science datasets from PREVENT-AD, a longitudinal cohort of pre-symptomatic Alzheimer's disease. Neuroimage Clin.;31:102733. DOI: https://doi.org/10.1016/j.nicl.2021.102733.
Van Essen DC, Smith SM, Barch DM, Behrens TEJ, Yacoub E, Ugurbil K. (2013). The WU-Minn Human Connectome Project: An overview. NeuroImage;80:62–79.
Wu D, Ma T, Ceritoglu C, Li Y, Chotiyanonta J, Hou Z, Hsu J, Xu X, Brown T, Miller MI, Mori S. (2016). Resource atlases for multi-atlas brain segmentations with multiple ontology levels based on T1-weighted MRI. Neuroimage;125:120-130; doi: https://doi.org/10.1016/j.neuroimage.2015.10.042.
Zhang SX, Heng PA, Liu ZJ. (2003). Atlas of Chinese Visible Human (Male and Female). Science Press, China, Bei Jing.
Zinchuk AV, Flanagan EP, Tubridy NJ, Miller WA, Mccullough LD. (2010). Attitudes of US medical trainees towards neurology education: "Neurophobia" - a global issue. BMC Med Educ 10: 49.
Zuo XN, He Y, Betzel RF, et al. (2017). Human connectomics across the life span. Trends in Cognitive Sciences;21(1):32-45.
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Acknowledgements
Many clinicians and institutions, through their collaboration as well as encouragement and endorsement of my long-term brain atlas-related work, motivated me to embark on this endeavor, including (but not limited to) Profs. Alim-Louis Benabid, R. Nick Bryan, David L. Cordozo, Michael V. Knopp, William W. Orrison, Anne G. Osborn, Albert L. Rhoton, Val M. Runge, Jean Talairach, Pierre Tournoux, and M. G. Yasargil; and the American Society of Neuroradiology, Radiological Society of North America, British Medical Association, Society for Brain Mapping and Therapeutics, and European Patent Office, as well as the publisher of my 15 brain atlases Thieme New York–Stuttgart and, especially, its former president Brian Scanlan.
I believe that the best way of expressing my deepest gratitude to each one of them has been to create this freely available and easily accessible resource that will be beneficial to the future generations of medical students, neuroeducators, clinicians, and neuroscientists, especially, in the less fortunate countries.
And last but not least, this work would not be possible without the invaluable contribution of my family, Anna and Natalia to atlas coloring and esthetic design, and Marta to repository development.
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Nowinski, W.L. NOWinBRAIN: a Large, Systematic, and Extendable Repository of 3D Reconstructed Images of a Living Human Brain Cum Head and Neck. J Digit Imaging 35, 98–114 (2022). https://doi.org/10.1007/s10278-021-00528-0
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DOI: https://doi.org/10.1007/s10278-021-00528-0