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Involvement of bone-marrow-derived cells in kidney fibrosis

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Abstract

Cellular mechanisms have been proposed in the pathogenesis of fibrotic processes in the kidney. In this setting, cell sources underlying the generation of matrix-producing cells in diseased kidneys have been categorized as activated resident stromal cells (e.g., fibroblasts, pericytes), infiltrating bone-marrow-derived cells (e.g., fibrocytes, T cells, macrophages), and cells derived from epithelial–mesenchymal transition/endothelial–mesenchymal transition. Among these cell sources, accumulating evidence has shed light on the involvement of bone-marrow-derived cells, including monocytes/macrophages, and a circulating mesenchymal progenitor cell, fibrocyte, in the progression of fibrosis in kidney. Bone-marrow-derived cells positive for CD45 or CD34, and type 1 (pro)collagen dependent on the chemokine and renin–angiotensin systems migrate into diseased kidneys and enhance synthesis matrix protein, cytokines/chemokines, and profibrotic growth factors, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating kidney fibrosis.

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Acknowledgments

TW is a recipient of a Grant-in-Aid from the Ministry of Education, Science, Sports and Culture in Japan and Takeda Science Foundation.

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Authors and Affiliations

  1. Division of Nephrology, Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan

    Takashi Wada

  2. Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan

    Norihiko Sakai & Shuichi Kaneko

  3. Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan

    Yoshio Sakai

  4. Department of Molecular Preventive Medicine, University of Tokyo, Tokyo, Japan

    Kouji Matsushima

  5. Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan

    Kengo Furuichi

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  1. Takashi Wada
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  2. Norihiko Sakai
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  3. Yoshio Sakai
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  4. Kouji Matsushima
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  5. Shuichi Kaneko
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  6. Kengo Furuichi
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Correspondence to Takashi Wada.

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Wada, T., Sakai, N., Sakai, Y. et al. Involvement of bone-marrow-derived cells in kidney fibrosis. Clin Exp Nephrol 15, 8–13 (2011). https://doi.org/10.1007/s10157-010-0372-2

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  • DOI: https://doi.org/10.1007/s10157-010-0372-2

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