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Secondary Resistance Among 554 Isolates of Helicobacter pylori After Failure of Therapy

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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

 In a study to determine secondary resistance among Helicobacter pylori isolates, gastroenterologists from several German cities submitted over a 3-year period to centre A (Regensburg) or centre B (Freiburg) gastric biopsies from patients in whom one or more therapies to eradicate Helicobacter pylori had failed. Rates of resistance among the collections of 302 (centre A) and 252 (centre B) isolates were, respectively, as follows: to metronidazole, 75% and 66%; to clarithromycin, 58% and 49%; to amoxicillin, 0%; to ciprofloxacin, 9%; to doxycycline, 0%; and to rifampin, 0%. Resistance to clarithromycin was associated with metronidazole resistance in 89% and 85% of the isolates in centre A and centre B, respectively.

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Authors and Affiliations

  1. Institute for Medical Microbiology and Hygiene, University of Freiburg, Hermann-Herder-Strasse 11, 79104 Freiburg, Germany e-mail: Markus-Heep@web.de, , , , , , DE

    M. Heep, M. Kist & S. Strobel

  2. Institut für Medizinische Mikrobiologie, Uniklinik Regensburg, Franz-Josef-Strauss-Allee 11, 93053 Regensburg, Germany, , , , , , DE

    D. Beck & N. Lehn

Authors
  1. M. Heep
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  2. M. Kist
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  3. S. Strobel
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  4. D. Beck
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  5. N. Lehn
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Heep, M., Kist, M., Strobel, S. et al. Secondary Resistance Among 554 Isolates of Helicobacter pylori After Failure of Therapy. EJCMID 19, 538–541 (2000). https://doi.org/10.1007/s100960000288

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  • DOI: https://doi.org/10.1007/s100960000288

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