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A quantitative study of the biotransformation of insulin-enhancing VO2+ compounds

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Abstract

Potentiometric (pH titrations) and spectroscopic (electron paramagnetic resonance) methods have been used to determine the thermodynamic stability constants of the various VO2+ complexes formed after the interaction of four insulin-enhancing vanadium compounds, [VO(6-mepic)2], cis-[VO(pic)2(H2O)], [VO(acac)2], and [VO(dhp)2], where 6-mepic, pic, acac, and dhp indicate the deprotonated forms of 6-methylpicolinic acid, picolinic acid, acetylacetone, and 1,2-dimethyl-3-hydroxy-4(1H)-pyridinone, with high molecular mass [human serum apotransferrin (hTf) and human serum albumin (HSA)] and low molecular mass (lactate) components of blood serum. In particular, log β values for the formation of (VO)hTf (13.0 ± 0.5), (VO)2hTf (25.5 ± 0.5), (VO)HSA (9.1 ± 1.0), (VO) 2 d HSA (20.9 ± 1.0), cis-VO(dhp)2(hTf) (25.5 ± 0.6), cis-VO(dhp)2(HSA) (25.9 ± 0.6), (VO)hTf(lact) (14.5 ± 0.8), (VO)2hTf(lact)2 (28.5 ± 0.8), (VO)hTf(pic) (15.6 ± 0.8), and (VO)2hTf(pic)2 (30.4 ± 0.8) were determined. The values of the stability constants were used to compare the calculated composition of ternary and quinary systems with that recently proposed by some of us through electron paramagnetic resonance and density functional theory methods (Sanna et al. in Inorg. Chem. 49:174–187, 2010) and to predict the distribution of VO2+ ion in blood serum when one of the four insulin-enhancing vanadium compounds studied, [VO(carrier)2], is administered.

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Authors and Affiliations

  1. Istituto CNR di Chimica Biomolecolare, Trav. La Crucca 3, 07040, Sassari, Italy

    Daniele Sanna

  2. Department of Inorganic and Analytical Chemistry, University of Debrecen, 4010, Debrecen, Hungary

    Péter Buglyó

  3. Dipartimento di Chimica and Centro Interdisciplinare per lo Sviluppo della Ricerca Biotecnologica e per lo Studio della Biodiversità della Sardegna, Università di Sassari, Via Vienna 2, 07100, Sassari, Italy

    Giovanni Micera & Eugenio Garribba

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  1. Daniele Sanna
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  4. Eugenio Garribba
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Correspondence to Eugenio Garribba.

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Sanna, D., Buglyó, P., Micera, G. et al. A quantitative study of the biotransformation of insulin-enhancing VO2+ compounds. J Biol Inorg Chem 15, 825–839 (2010). https://doi.org/10.1007/s00775-010-0647-9

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  • DOI: https://doi.org/10.1007/s00775-010-0647-9

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