Abstract
The incidence of ciliated cells in the prostate gland of the female gerbil (Meriones unguiculatus) is uncommon and apparently becomes more frequent during androgen (testosterone cypionate) and anti-estrogen (letrozole) endocrine therapies. To evaluate the effects of such drug therapies on the induction of ciliogenesis in the glandular epithelium of female prostate glands, adult female gerbils aged 90 days were treated for 14 days with testosterone and letrozole after which their prostate glands were removed for histological, ultrastructural, and serological analyses. The cytodifferentiation of the ciliated phenotype in the alveolar epithelium became more frequent after both the testosterone and the letrozole treatments. The ciliogenesis phenomenon of the epithelial cells in the prostate gland of female gerbils thus appears to be induced by variations in the increase of androgen levels.
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Acknowledgements
Comments provided by anonymous referees helped to improve our original manuscript. We are grateful to Mrs. Rosana S. Sousa for her technical assistance and to biology student, Rodrigo P. Leite, for help and suggestions and thank all other researchers at the Microscopy and Microanalysis Laboratory. Acknowledgements are also due to Dr. Peter J. Harris, Ricardo S. Sobreira, and Mr. James Welsh for English-language revision of this paper. Special thanks are extended to Ana Maria G. Custódio for suggestions and advice.
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This paper is part of the thesis presented by F.C.A.S. to the Institute of Biology, UNICAMP, in partial fulfillment of the requirement for a PhD degree.
This work was supported by grants from the Brazilian agencies CAPES - Coordinating Body for Training University-level Personnel (fellowship to F.C.A.S.) FAPESP - São Paulo Research Foundation (Proc. Nr. 00/11648-1) and CNPq - Brazilian National Research and Development Council (Proc. Nr. 301111/05-7 research fellowship to S.R.T.).
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Santos, F.C.A., Falleiros-Júnior, L.R., Corradi, L.S. et al. Experimental endocrine therapies promote epithelial cytodifferentiation and ciliogenesis in the gerbil female prostate. Cell Tissue Res 328, 617–624 (2007). https://doi.org/10.1007/s00441-007-0381-y
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DOI: https://doi.org/10.1007/s00441-007-0381-y