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Activation of hepatic natural killer cells and control of liver-adapted lymphoma in the murine model of cytomegalovirus infection

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Abstract

Hematopoietic stem cell transplantation (HSCT) is a promising therapeutic option against hematopoietic malignancies. Infection with cytomegalovirus (CMV) and tumor relapse are complications that limit the success of HSCT. In theory, CMV infection can facilitate tumor relapse and growth by inhibiting “graft take” and reconstitution of the immune system or by inducing the secretion of tumor cell growth-promoting cytokines. Conversely, one can also envisage an anti-tumoral effect of CMV by cytopathic/oncolytic infection of tumor cells, by inducing the secretion of death ligands for tumor cell apoptosis, and by the activation of systemic innate and adaptive immunity. Here we will briefly review the current knowledge about tumor control in a murine model of CMV infection and liver-adapted B cell lymphoma, with a focus on a putative implication of CD49+NKG2D+ hepatic natural killer cells.

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Acknowledgments

We greatly appreciate the help by Jürgen Olert (Institute for Pathology, Mainz) with the karyotype analysis and by Hans Anton Lehr (Institute for Pathology, Mainz) with the Gomori staining of liver tissue. We thank Christof K. Seckert from our institute for help with the isolation of non-parenchymal liver cells. This work was supported by the Deutsche Forschungsgemeinschaft, SFB 432, individual project A10 “Influence of cytomegalovirus infection on the risk of tumor relapse after bone marrow transplantation”.

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Authors and Affiliations

  1. Institute for Virology, Johannes Gutenberg University, Obere Zahlbacher Strasse 67, Hochhaus am Augustusplatz, 55131, Mainz, Germany

    Katja C. Erlach, Verena Böhm, Martin Knabe, Petra Deegen, Matthias J. Reddehase & Jürgen Podlech

Authors
  1. Katja C. Erlach
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  2. Verena Böhm
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  3. Martin Knabe
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  4. Petra Deegen
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  5. Matthias J. Reddehase
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  6. Jürgen Podlech
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Correspondence to Katja C. Erlach or Jürgen Podlech.

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There are inclusions in this text reproduced or recombined from previous articles published in the Journal of Virology (American Society for Microbiology), which are cited in the reference section.

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Erlach, K.C., Böhm, V., Knabe, M. et al. Activation of hepatic natural killer cells and control of liver-adapted lymphoma in the murine model of cytomegalovirus infection. Med Microbiol Immunol 197, 167–178 (2008). https://doi.org/10.1007/s00430-008-0084-3

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  • DOI: https://doi.org/10.1007/s00430-008-0084-3

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