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Photodynamic therapy for recurrent hyphema after proton beam radiotherapy of iris melanoma

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Abstract

Background

Recurrent hemorrhage with secondary glaucoma is a rare but serious complication following proton beam irradiation (PBI) of iris melanoma. We report a case in which photodynamic therapy (PDT) was successfully used to treat this complication.

Methods

The history, clinical features and management of a patient with iris melanoma who was treated with PBI and later developed recurrent hyphema and increased intraocular pressure are presented. PDT was used to treat the abnormal intralesional blood vessels which caused the recurrent intraocular haemorrhage.

Results

The intralesional blood vessels regressed following PDT. The patient did not experience any further episodes of hyphema or elevated intraocular pressure.

Conclusions

Our case demonstrates that the vascular abnormalities following irradiation of iris melanoma may respond favorably to PDT in selected cases. To our knowledge, this is the first reported case in which PDT was used to treat recurrent hyphema caused by abnormal intralesional blood vessels after proton beam irradiation of iris melanoma.

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Authors and Affiliations

  1. St Paul’s Eye Unit, Oncology Service, Royal Liverpool University Hospital, Liverpool, UK

    Nikolaos Trichopoulos & Bertil Damato

  2. Department of Ophthalmology, University of Cincinnati College of Medicine, Health Professions Building, Suite#350, 3223 Eden Avenue, Cincinnati, OH, 45267-0527, USA

    Nikolaos Trichopoulos

Authors
  1. Nikolaos Trichopoulos
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  2. Bertil Damato
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Corresponding author

Correspondence to Nikolaos Trichopoulos.

Additional information

The authors have full control of all primary data, and agree to allow Graefe’s Archive for Clinical and Experimental Ophthalmology to review their data upon request.

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Trichopoulos, N., Damato, B. Photodynamic therapy for recurrent hyphema after proton beam radiotherapy of iris melanoma. Graefes Arch Clin Exp Ophthalmol 245, 1573–1575 (2007). https://doi.org/10.1007/s00417-007-0584-7

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  • DOI: https://doi.org/10.1007/s00417-007-0584-7

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