Abstract.
Centromeric rearrangements, in the form of isochromosomes or whole-arm translocations, are the most common recurrent changes in head and neck and skin carcinomas. Little is known about the mechanisms behind the origin of these chromosome rearrangements. In the present study, one basal cell carcinoma and two squamous cell carcinomas of the head and neck were thoroughly studied by cytogenetic and fluorescence in situ hybridization techniques. All tumors showed intratumor heterogeneity in the form of cytogenetically related subclones (in all tumors) and unrelated clones (in one tumor). Assessment of karyotypic evolution in these tumors suggests that centromeric cleavage is a mechanism giving rise to isochromosomes. A similar mechanism may also be involved in the formation of whole-arm translocations.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
In revised form: 10 May 2000
Electronic Publication
Rights and permissions
About this article
Cite this article
Jin, Y., Jin, C., Salemark, L. et al. Centromere cleavage is a mechanism underlying isochromosome formation in skin and head and neck carcinomas. Chromosoma 109, 476–481 (2000). https://doi.org/10.1007/s004120000107
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s004120000107