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Dietary total antioxidant capacity and mortality in the PREDIMED study

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A Correction to this article was published on 08 December 2021

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Abstract

Purpose

The aim of the present study was to assess the association between the dietary total antioxidant capacity, the dietary intake of different antioxidants and mortality in a Mediterranean population at high cardiovascular disease risk.

Methods

A total of 7,447 subjects from the PREDIMED study (multicenter, parallel group, randomized controlled clinical trial), were analyzed treating data as an observational cohort. Different antioxidant vitamin intake and total dietary antioxidant capacity were calculated from a validated 137-item food frequency questionnaire at baseline and updated yearly. Deaths were ascertained through contact with families and general practitioners, review of medical records and consultation of the National Death Index. Cox regression models were fitted to assess the relationship between dietary total antioxidant capacity and mortality. Dietary total antioxidant capacity was estimated using ferric-reducing antioxidant power assays.

Results

A total of 319 deaths were recorded after a median follow-up of 4.3 years. Subjects belonging to the upper quintile of antioxidant capacity were younger, ex-smokers, with high educational level, and more active and had higher alcohol intake. Multivariable-adjusted models revealed no statistically significant difference between total dietary antioxidant capacity and mortality (Q5 vs. Q1 ref HR 0.85; 95 % CI 0.60–1.20) neither for the intake of all the vitamins studied.

Conclusions

No statistically significant association was found between antioxidant capacity and total mortality in elderly subjects at high cardiovascular risk.

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Acknowledgments

The authors want to thank the participants of the study for their collaboration and the PREDIMED personnel for their excellent assistance with all aspects of the trial. This study was funded by the Spanish Ministry of Health (ISCIII), CIBEROBN, PI1001407, G03/140, RD06/0045 and the Autonomous Government of Catalonia, and Caixa Tarragona (10-1343). The Fundación Patrimonio Comunal Olivarero and Hojiblanca SA (Málaga, Spain), California Walnut Commission (Sacramento, CA), Borges SA (Reus, Spain) and Morella Nuts SA (Reus, Spain), donated the olive oil, walnuts, almonds and hazelnuts, respectively. None of the funding sources played a role in the design, collection, analysis, interpretation or publication of the data. AG is supported by a FPU fellowship from the Spanish Government.

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain

    P. Henríquez-Sánchez, A. Sánchez-Villegas, C. Ruano-Rodríguez, A. Gea, R. M. Lamuela-Raventós, R. Estruch, J. Salas-Salvadó, M. I. Covas, D. Corella, M. Gutiérrez-Bedmar, J. M. Santos-Lozano, X. Pintó, F. Arós, M. Fiol, A. Tresserra-Rimbau, E. Ros, M. A. Martínez-González & L. Serra-Majem

  2. Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain

    P. Henríquez-Sánchez, A. Sánchez-Villegas, C. Ruano-Rodríguez & L. Serra-Majem

  3. Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Navarra, Spain

    A. Gea & M. A. Martínez-González

  4. Nutrition and Food Science Department, XaRTA, INSA, School of Pharmacy, University of Barcelona, Barcelona, Spain

    R. M. Lamuela-Raventós & A. Tresserra-Rimbau

  5. Department of Internal Medicine, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain

    R. Estruch

  6. Human Nutrition Unit, School of Medicine, University Rovira i Virgili, Reus, Spain

    J. Salas-Salvadó

  7. Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición, Instituto de Salud Carlos II, Madrid, Spain

    M. I. Covas

  8. Cardiovascular Risk and Nutrition Research Unit, Institut Municipal d’Investigació Mèdica (IMIM), Barcelona, Spain

    M. I. Covas

  9. Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain

    D. Corella

  10. CIBER Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain

    H. Schröder

  11. Cardiovascular Risk and Nutrition Research Group, Institut Municipal d’Investigació Medica (IMIM)-Institut de Recerca del Hospital del Mar, Barcelona, Spain

    H. Schröder

  12. Department of Preventive Medicine, University of Malaga, Málaga, Spain

    M. Gutiérrez-Bedmar

  13. Department of Family Medicine, Primary Care Division of Sevilla, San Pablo Health Center, Seville, Spain

    J. M. Santos-Lozano

  14. Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, Hospitalet de Llobregat, Barcelona, Spain

    X. Pintó

  15. Department of Cardiology, University Hospital of Alava, Vitoria, Spain

    F. Arós

  16. Institute of Health Sciences, University of Balearic Islands, Palma de Mallorca, Spain

    M. Fiol

  17. Hospital Son Espases, Palma de Mallorca, Spain

    M. Fiol

  18. Lipid Clinic, Endocrinology and Nutrition Service, Institut d’Investigacions Biomèdiques August Pi Sunyer, Hospital Clinic, Barcelona, Spain

    E. Ros

Authors
  1. P. Henríquez-Sánchez
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  2. A. Sánchez-Villegas
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  3. C. Ruano-Rodríguez
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  4. A. Gea
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  5. R. M. Lamuela-Raventós
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  6. R. Estruch
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  7. J. Salas-Salvadó
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  8. M. I. Covas
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  9. D. Corella
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  10. H. Schröder
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  11. M. Gutiérrez-Bedmar
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  12. J. M. Santos-Lozano
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  13. X. Pintó
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  14. F. Arós
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  15. M. Fiol
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  16. A. Tresserra-Rimbau
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  17. E. Ros
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  18. M. A. Martínez-González
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  19. L. Serra-Majem
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Corresponding author

Correspondence to P. Henríquez-Sánchez.

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On behalf of the PREDIMED Study Investigators.

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Henríquez-Sánchez, P., Sánchez-Villegas, A., Ruano-Rodríguez, C. et al. Dietary total antioxidant capacity and mortality in the PREDIMED study. Eur J Nutr 55, 227–236 (2016). https://doi.org/10.1007/s00394-015-0840-2

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  • DOI: https://doi.org/10.1007/s00394-015-0840-2

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