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Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet

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Abstract

Purpose

Adipose tissue is central to the regulation of energy balance. Two functionally different fat pads are present in mammals: white adipose tissue, the primary site of triglyceride storage, and brown adipose tissue (BAT), which is specialized in heat production. In this context, new strategies capable of modulating the development and function of white and BAT become relevant. In the present study, we analyzed the influence of resveratrol (sirtuin activator) on energy balance and the expression of thermogenesis markers.

Methods

Mice were divided into two groups: standard diet (ST) and standard diet plus resveratrol (ST + RSV).

Results

After 2 months of treatment, ST + RSV mice presented significantly decreased fat accumulation in adipose tissue, with diminished total cholesterol and glucose plasma levels. Additionally, increased oxygen consumption was observed in ST + RSV group. Analyses of mRNA of thermogenesis-related genes showed significant increase in UCP1, SIRT1, PTEN and BMP-7 expression in BAT.

Conclusion

Our data suggest that improved metabolism produced by oral administration of resveratrol is, at least in part, associated with increased thermogenesis followed by high expression of UCP1 and SIRT1, which can mediate higher energy expenditure and decreased fat accumulation in adipose tissue.

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Acknowledgments

This work was partially supported by the Coordination for the Improvement of Higher Education Personnel (CAPES), National Council for Scientific and Technological Development (CNPq) and Minas Gerais State Foundation for Research Development (FAPEMIG).

Conflict of interest

There is no conflict of interest to disclose for any of the authors.

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Authors and Affiliations

  1. Pharmacology Department, Biological Sciences Institute, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    Alessandra Caroline Montes Frade, Kátia Michelle Freitas, Miriam Teresa Paz Lopes & Sérgio Henrique Sousa Santos

  2. Physiology and Biophysics Department, Biological Sciences Institute, Federal University of Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil

    Juliana Bohnen Guimarães & Cândido Celso Coimbra

  3. Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros (UNIMONTES), Montes Claros, Minas Gerais, Brazil

    João Marcus Oliveira Andrade, André Luiz Sena Guimarães, Alfredo Maurício Batista de Paula & Sérgio Henrique Sousa Santos

  4. Departamento de Farmacologia, Universidade Federal de Minas Gerais, Av. Antônio Carlos 6627-ICB, Belo Horizonte, Minas Gerais, 31270-901, Brazil

    Sérgio Henrique Sousa Santos

Authors
  1. João Marcus Oliveira Andrade
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  2. Alessandra Caroline Montes Frade
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  3. Juliana Bohnen Guimarães
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  7. Alfredo Maurício Batista de Paula
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  8. Cândido Celso Coimbra
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  9. Sérgio Henrique Sousa Santos
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Corresponding author

Correspondence to Sérgio Henrique Sousa Santos.

Additional information

João Marcus Oliveira Andrade and Alessandra Caroline Montes Frade equally contributed to this study.

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Andrade, J.M.O., Frade, A.C.M., Guimarães, J.B. et al. Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet. Eur J Nutr 53, 1503–1510 (2014). https://doi.org/10.1007/s00394-014-0655-6

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  • DOI: https://doi.org/10.1007/s00394-014-0655-6

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