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Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris

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Abstract

Postprandial hypertriglyceridemia and hyperglycemia may promote endothelial and hemorheological dysfunction. The present study investigated the effects of pravastatin on endothelial function and hemorheology in patients with stable angina pectoris (AP) before and after eating a test meal. We recruited 26 patients with stable AP who had impaired glucose tolerance and mild dyslipidemia and six healthy men as controls to assess endothelial function and hemorheological behavior. In each group, we measured forearm blood flow (FBF) during post-ischemic reactive hyperemia and obtained blood samples before and 2 h after the test meal. Pravastatin 20 mg/day was then commenced in the 26 AP patients. The above tests were repeated after 2 days and 6 months. Maximum FBF during hyperemia in the baseline fasting phase was significantly lower in the AP patients than in the controls (p < 0.05). Fasting and postprandial FBF during reactive hyperemia time-dependently improved after pravastatin treatment (p < 0.05 vs. baseline data for each phase). Pravastatin treatment for 6 months, but not for 2 days, inhibited leukocyte activation and improved hemorheological parameters. In conclusion, pravastatin treatment for 6 months improved fasting and postprandial endothelial and hemorheological dysfunction in AP patients.

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Acknowledgements

The authors wish to thank Mrs. Sachimi Jimbo for the preparation and measurement of FBF via plethysmography and WBTT using the MC-FAN and Dr. Ikunosuke Sakurabayashi for the measurement of the lipid profile of each sample. We would like to thank Editage (http://www.editage.jp) for English language editing.

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Authors and Affiliations

  1. Department of Integrated Medicine 1, Saitama Medical Center, Jichi Medical University, Saitama, 330-8503, Japan

    Tomio Umemoto, Kenshiro Arao, Nahoko Ikeda, Masanobu Kawakami, Hideo Fujita & Shin-ichi Momomura

  2. Department of Cardiovascular Medicine and Nephrology, Dokkyo Medical University Nikko Medical Center, 632 Takatoku, Nikko, Tochigi, 321-2593, Japan

    Takanori Yasu

  3. Department of Internal Medicine, Nerima Hikarigaoka General Hospital, Nerima, Tokyo, 179-0072, Japan

    Kenshiro Arao & Masanobu Kawakami

  4. Department of Cardiology, Dokkyo Medical University Nikko Medical Center, Nikko, Japan

    Yasuto Horie & Hiroyuki Sugimura

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  1. Tomio Umemoto
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  2. Takanori Yasu
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Correspondence to Takanori Yasu.

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This work was partly supported by Grants-in-Aid from the Ministry of Education, Science and Culture of Japan (26350581 to TY).

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Umemoto, T., Yasu, T., Arao, K. et al. Pravastatin improves postprandial endothelial dysfunction and hemorheological deterioration in patients with effort angina pectoris. Heart Vessels 32, 1051–1061 (2017). https://doi.org/10.1007/s00380-017-0974-7

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