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Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis

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Abstract

Moderate wine intake is associated with a reduced risk of morbidity and mortality from cardiovascular disease. Atherosclerosis is enhanced in arterial segments exposed to disturbed flow. Perturbed shear stress increases also the endothelial expression of oxidation-sensitive responsive genes (such as ELK-1 and p-JUN). This study evaluates the effects of chronic consumption of red wine on perturbed shear stress-induced atherogenesis. Results indicated that chronic treatment with red wine significantly attenuated the activation of redox-sensitive genes (ELK-1 and p-JUN) and increased endothelial nitric oxide synthase (eNOS) expression (which was decreased by perturbed shear stress) in cultured human coronary endothelial cells (EC) and in atherosclerosis-prone areas of hypercholesterolemic mice. Oral administration of red wine to hypercholesterolemic mice reduced significantly the progression of atherosclerosis. Moreover, short-term supplementation with red wine to C57BL/6J mice significantly increased upregulation of aortic eNOS and SIRT1 expression induced by physical training. These findings establish that administration of low doses of red wine can attenuate the proatherogenic effects induced by perturbed shear stress in vitro and in vivo. This evidence may have implications for the prevention of atherosclerotic lesion progression and its clinical manifestations.

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Authors and Affiliations

  1. Department of General Pathology, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Complesso S. Andrea delle Dame, Via L. de Crecchio 7, Naples, 80138, Italy

    Claudio Napoli, Vincenzo Sica & Concetta Schiano

  2. Excellence Research Center of Cardiovascular Diseases, Division of Clinical Pathology, 1st School of Medicine, II University of Naples, Naples, Italy

    Claudio Napoli

  3. Evans Department of Medicine, Boston University, Boston, USA

    Claudio Napoli

  4. Department of Chemical Biology and Physics, II University of Naples, Naples, Italy

    Maria Luisa Balestrieri & Luigi Servillo

  5. Division of Hypertension, Mayo Clinic Foundation, Rochester, USA

    Lilach O. Lerman

  6. Department of Anesthesiology, University of Novara, Novara, Italy

    Ettore Crimi

  7. Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, USA

    Ettore Crimi

  8. Department of Human Pathology, Federico II University of Naples, Naples, Italy

    Gaetano De Rosa & Francesco P. D’Armiento

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  1. Claudio Napoli
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  2. Maria Luisa Balestrieri
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  9. Francesco P. D’Armiento
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Correspondence to Claudio Napoli.

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These two authors contributed equally to this study.

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Napoli, C., Balestrieri, M.L., Sica, V. et al. Beneficial effects of low doses of red wine consumption on perturbed shear stress-induced atherogenesis. Heart Vessels 23, 124–133 (2008). https://doi.org/10.1007/s00380-007-1015-8

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  • DOI: https://doi.org/10.1007/s00380-007-1015-8

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