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Assessment of aortic stiffness and ventricular diastolic functions in patients with Behçet’s disease

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Abstract

Background: Behçet’s disease is a systemic vasculitis in which studies have given conflicting results about ventricular diastolic functions. However, tissue Doppler echocardiography has never been used in any of these studies. Aortic stiffness, a cardiovascular risk factor, may also precede ventricular dysfunction. Objectives: The aim of this study was to assess aortic stiffness and biventricular diastolic functions in patients with Behçet’s disease. Methods: A total of 26 patients with Behçet’s disease (mean age; 33±10 years) and 20 age- and sex-matched controls (mean age; 33±7 years) were included. Aortic stiffness was evaluated by aortic strain and distensibility. Ventricular diastolic functions were evaluated with both conventional and tissue Doppler echocardiography. Mitral E and A wave, E/A ratio of E wave, deceleration time, and isovolumic relaxation time were calculated. Results: There was no significant difference in diastolic Doppler parameters between patients and controls. Similarly, there was no significant difference in mitral annular E and A velocities between these two groups. Aortic strain in patients with Behçet’s disease was found to be significantly less than in the controls (8.3±4.9% and 15.7±2.7% respectively, p<0.001). Aortic distensibility was also significantly low in patients with Behçet’s disease when compared to controls (0.45±0.28 and 0.78±0.13 respectively, p<0.001). Beta index values were significantly high in Behçet’s patients (7.23±5.93 and 2.69±0.55 respectively, p<0.001). Conclusion: No significant diastolic dysfunction was found in left and right ventricles in patients with Behçet’s disease by using both conventional and tissue Doppler echocardiography. However, an increase in aortic stiffness was found, suggesting an inflammatory involvement of proximal aorta.

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Authors and Affiliations

  1. Department of Internal Medicine, Division of Rheumatology, Suleyman Demirel University Faculty of Medicine, Istanbul Cad. No:33/8, 32200, Isparta, Turkey

    S. Ercan. Tunc, Cagatay Arslan & Mehmet Sahin

  2. Department of Cardiology, Suleyman Demirel University Faculty of Medicine, Isparta, Turkey

    Abdullah Dogan & Omer Gedikli

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  1. S. Ercan. Tunc
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  2. Abdullah Dogan
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Correspondence to S. Ercan. Tunc.

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Tunc, S.E., Dogan, A., Gedikli, O. et al. Assessment of aortic stiffness and ventricular diastolic functions in patients with Behçet’s disease. Rheumatol Int 25, 447–451 (2005). https://doi.org/10.1007/s00296-004-0558-6

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  • DOI: https://doi.org/10.1007/s00296-004-0558-6

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