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Reduction of Intimal Hyperplasia withRe-188-labeled Stents in a Rabbit Model at 7and 26 Weeks: An Experimental Study

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Abstract

The aim of this study was to analyze the feasibility of 188Re-labeled stents to reduce neointimal formation in a rabbit atherosclerosis model and to test the long-term effects at 7 and 26 weeks. Fifty-nine male New Zealand White rabbits were fed a 0.5% cholesterol diet for 4 weeks before balloon angioplasty and insertion of Palmaz stents in the infrarenal aorta. The animals were sacrificed 7 and 26 weeks after stent implantation. Control stents were compared with 188Re stents: (dose 1) 11.3 ± 1.8 MBq; (dose 2) 37.3 ± 4.2 MBq, and (dose 3) 80.1 ± 7.8 MBq. Each activity group consisted of a short-term (7 weeks) and a long-term group (26 weeks), resulting in a total of eight study groups. No thrombotic occlusion was observed. The neointimal formation in the control group was 2.11 [95% confidence interval (CI): 0.68–6.52] mm2 at 7 weeks and 2.10 (0.62–7.11) at 26 weeks. In the treatment groups, neointima reduction was detectable at 7 weeks [dose 1: 0.33 (0.09–1.22) mm2; dose 2: 0.17 (0.05–0.57) mm2; dose 3: 0.03 (0.01–0.13) mm2]. After 26 weeks, a catch-up of neointimal formation in the radioactive groups was most obvious in the low-dose group [dose 1: 0.80 (0.28–2.29) mm2; dose 2: 0.18([0.06–0.52) mm2; dose 3: 0.50 (0.17–1.42) mm2]. Compared to the long-term control group, neointimal reduction was still >60%. No induction of neointimal formation was observed at the edges of the stents. Radiation resulted in delayed re-endothelialization. 188Re stents were capable to reduce intimal hyperplasia and did not cause thrombosis. The edge effect, which was the major limitation of 32P stents, was not observed in 188Re stents.

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Authors and Affiliations

  1. Department of Diagnostic Radiology, University of Tübingen, Tübingen, Germany

    Gunnar Tepe, Tobias Dietrich, Franziska Grafen & Claus D. Claussen

  2. Department of Occupational and Social Medicine, University of Tübingen, Tübingen, Germany

    Ute Brehme

  3. Research Laboratories of Schering AG, Berlin, Germany

    Peter Muschick & Ludger M. Dinkelborg

  4. Institute of Pathology, University of Tübingen, Tübingen, Germany

    Annette Greschniok

  5. Department of Radiology, The Jewish Hospital, Berlin, Germany

    Stephan H. Duda

Authors
  1. Gunnar Tepe
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  2. Tobias Dietrich
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  3. Franziska Grafen
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  4. Ute Brehme
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  5. Peter Muschick
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  6. Ludger M. Dinkelborg
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  7. Annette Greschniok
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  8. Claus D. Claussen
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  9. Stephan H. Duda
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Correspondence to Gunnar Tepe.

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Tepe, G., Dietrich, T., Grafen, F. et al. Reduction of Intimal Hyperplasia withRe-188-labeled Stents in a Rabbit Model at 7and 26 Weeks: An Experimental Study. Cardiovasc Intervent Radiol 28, 632–637 (2005). https://doi.org/10.1007/s00270-004-0308-x

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