Abstract
Summary
Currently used diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. These diagnostic measures associate differently to bone mineral density (BMD), as an example of muscle-related clinical outcome. These differences should be taken into account when studying sarcopenia.
Introduction
Diagnostic measures for sarcopenia utilize different measures of muscle mass, muscle strength, and physical performance. To understand differences between these measures, we determined the association with respect to whole body BMD, as an example of muscle-related clinical outcome.
Methods
In the European cross-sectional study MYOAGE, 178 young (18–30 years) and 274 healthy old participants (69–81 years) were recruited. Body composition and BMD were evaluated using dual-energy X-ray densitometry. Diagnostic measures for sarcopenia were composed of lean mass as percentage of body mass, appendicular lean mass (ALM) as percentage of body mass, ALM divided by height squared (ALM/height2), knee extension torque, grip strength, walking speed, and Timed Up and Go test (TUG). Linear regression models were stratified for sex and age and adjusted for age and country, and body composition in separate models.
Results
Lean mass and ALM/height2 were positively associated with BMD (P < 0.001). Significance remained in all sex and age subgroups after further adjustment for fat mass, except in old women. Lean mass percentage and ALM percentage were inversely associated with BMD in old women (P < 0.001). These inverse associations disappeared after adjustment for body mass. Knee extension torque and handgrip strength were positively associated with BMD in all subgroups (P < 0.01), except in old women. Walking speed and TUG were not related to BMD.
Conclusions
The associations between diagnostic measures of sarcopenia and BMD as an example of muscle-related outcome vary widely. Differences between diagnostic measures should be taken into account when studying sarcopenia.
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Acknowledgments
This study was supported by an unrestricted grant from the seventh framework program MYOAGE (HEALTH-2007-2.4.5-10), 050-060-810 The Netherlands Consortium for Healthy Aging (NCHA)), Estonian Science Foundation (grants # 8736 and #7823), the Estonian Ministry of Education and Research (grant SF01080114As08), and the Association Francais contres les Myopathies (AFM), Inserm, Université Pierre et Marie Curie (UPMC), the CNRS. The authors thank M. van der Bij, T.M. Maden-Wilkinson, and Dr. I. Kull for support, and E. Klaus; Dr. J. Ereline; Dr. T. Kums, MSc; H Aibast; and C Levergeois for their skillful technical assistance.
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Bijlsma, A.Y., Meskers, M.C.G., Molendijk, M. et al. Diagnostic measures for sarcopenia and bone mineral density. Osteoporos Int 24, 2681–2691 (2013). https://doi.org/10.1007/s00198-013-2376-8
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DOI: https://doi.org/10.1007/s00198-013-2376-8