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Extended monod kinetics for substrate inhibited systems

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Abstract

The biochemical route is identified to be one of the simplest and cheapest means by which valuable chemicals are being synthesized. Microorganisms play a vital role in carrying out these processes. However, the kinetic studies relevant to this process is scarce. Most often inhibition effects due to either cells or substrates or products affect the performance of such processes. This paper deals with the study of various model equations for substrate inhibition kinetics. An attempt has been made to study the applicability of various model equations for substrate inhibited systems by fitting their experimental data and evaluating various parameters including the standard deviations in each case. Finally, a new model has been brought out which gives the best fit for almost all the systems.

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Abbreviations

C s g/l:

substrate concentration

C s0 g/l:

threshold substrate concentration

K Ig/l:

inhibition constant

k m, Ksg/l:

half saturation constant of growth kinetics

m, n :

constants

μ 1/h:

specific growth rate

μ max 1/h:

maximal specific growth rate

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Authors and Affiliations

  1. Centre for Biosciences and Biotechnology, Indian Institute of Technology, 600 036, Madras, India

    A. Sivakumar, T. Srinivasaraghavan, T. Swaminathan & A. Baradarajan

Authors
  1. A. Sivakumar
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  2. T. Srinivasaraghavan
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  3. T. Swaminathan
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  4. A. Baradarajan
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Additional information

The authors wish to thank Mr. S. Venkatesan for the excellent typing of the manuscript.

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Sivakumar, A., Srinivasaraghavan, T., Swaminathan, T. et al. Extended monod kinetics for substrate inhibited systems. Bioprocess Engineering 11, 185–188 (1994). https://doi.org/10.1007/BF00369628

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  • DOI: https://doi.org/10.1007/BF00369628

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