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Time Trends and Sex Patterns in Hodgkin’s Disease Incidence in Canada, 1970–1995

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Abstract

Purpose: To examine time trends and sex patterns in Hodgkin’s disease incidence in Canada, from 1970 through 1995.

Method: In addition to analyses of the secular trends and sex ratio in incidence rates, ageperiod-cohort models were fitted to estimate the effects on the trends. Age-specific male/female incidence rate ratios were examined for the disease and for its two major histologic subtypes.

Results: The overall age-adjusted incidence rate of Hodgkin’s disease decreased significantly in males (3.5 per 100,000 in 1970–71 to 2.8 in 1994–95) but only slightly in females (2.4 per 100,000 to 2.3). There was a significant increase in the incidence among females aged 10–29 and among males aged 10–24, but a dramatic decrease among older ages. Age-period-cohort modelling showed that birth cohort and period effects were responsible for the observed trends in males and females, respectively.

Conclusion: The risk factors responsible for Hodgkin’s disease are different in females and males. Reproductive factors are likely to be associated with the occurrence of the disease in young women.

Résumé

But: Examiner les tendances temporelles et les répartitions par sexe de l’incidence de la maladie de Hodgkin au Canada, de 1970 à 1995.

Méthode: En plus des analyses des tendances à long terme et du sex-ratio dans les taux d’incidence, des modèles utilisant des cohortes fondées sur les périodes de la vie ont été intégrés pour estimer les effets sur les tendances. Les ratios d’incidence hommes/femmes pour des groupes d’âge déterminés ont été examinés pour la maladie de Hodgkin et pour deux grands sous-types histologiques.

Résultats: Le taux global d’incidence de la maladie de Hodgkin ajusté en fonction de l’âge a baissé sensiblement chez les hommes (de 3,5 à 2,8 pour 100 000 hommes entre 1970–71 et 1994–95) mais il a peu changé pour les femmes (de 2,4 à 2,3 pour 100 000 femmes). On a observé une augmentation notable de l’incidence parmi les personnes de sexe féminin de 10 à 29 ans et parmi les personnes de sexe masculin de 10 à 24 ans, mais un fléchissement marqué parmi les groupes plus âgés. Les modèles fondés sur les cohortes par périodes de la vie démontraient que les effets des cohortes de naissance et les effets des périodes de la vie étaient responsables des tendances observées chez les personnes d’un sexe comme de l’autre.

Conclusion: Les facteurs de risque responsables de la maladie de Hodgkin sont différents chez les femmes et chez les hommes. Il est probable que des facteurs liés à la reproduction ont un rapport avec l’occurrence de la maladie chez les jeunes de sexe féminin.

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Authors and Affiliations

  1. Laboratory Centre for Disease Control, Health Canada, Ottawa, Ontario, Canada

    Shiliang Liu MB, PhD, Robert Semenciw MSc, Chris Waters BSc, Shi Wu Wen MB, PhD &  Yang Mao PhD

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  1. Shiliang Liu MB, PhD
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  2. Robert Semenciw MSc
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  3. Chris Waters BSc
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  4. Shi Wu Wen MB, PhD
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  5. Yang Mao PhD
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Correspondence to Yang Mao PhD.

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Liu, S., Semenciw, R., Waters, C. et al. Time Trends and Sex Patterns in Hodgkin’s Disease Incidence in Canada, 1970–1995. Can J Public Health 91, 188–192 (2000). https://doi.org/10.1007/BF03404269

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  • DOI: https://doi.org/10.1007/BF03404269

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