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Possible effects of progesterone on human central nervous system and neurogenic tumors

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References

  1. Inoue T, Akahira. J, Takeyama J, et al. Spatial and topological distribution of progesterone receptor A and B isoforms during human development. Mol Cell Endocrinol 2001, 182: 83–9.

    Article  CAS  PubMed  Google Scholar 

  2. Baulieu EE, Robel P. Neurosteroids: a new brain function? J Steroid Biochem Mol Biol 1990, 37: 395–403.

    Article  CAS  PubMed  Google Scholar 

  3. Robel P, Baulieu EE. Neurosteroids: biosynthesis and function. Crit Rev Neurobiol 1995, 9: 383–94.

    CAS  PubMed  Google Scholar 

  4. Inoue T, Akahira J, Suzuki T, et al. Progesterone production and actions in the human central nervous system and neurogenic tumors. J Clin Endocrinol Metab 2002, 87: 5325–31.

    Article  CAS  PubMed  Google Scholar 

  5. Koenig HL, Schumacher M, Ferzaz B, et al. Progesterone synthesis and myelin formation by Schwann cells. Science 1995, 268: 1500–3.

    Article  CAS  PubMed  Google Scholar 

  6. Schumacher M, Robel P, Baulieu EE. Development and regeneration of the nervous system: a role for neurosteroids. Dev Neurosci 1996, 18: 6–21.

    Article  CAS  PubMed  Google Scholar 

  7. Lachance Y, Luu-The V, Verreault H, et al. Structure of the human type II 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase (3 beta-HSD) gene: adrenal and gonadal specificity. DNA Cell Biol 1991, 10: 701–11.

    Article  CAS  PubMed  Google Scholar 

  8. Waterman MR. A rising StAR: an essential role in cholesterol transport. Science 1995, 267: 1780–1.

    Article  CAS  PubMed  Google Scholar 

  9. Baulieu EE. Neurosteroids: of the nervous system, by the nervous system, for the nervous system. Recent Prog Horm Res 1997, 52: 1–32.

    CAS  PubMed  Google Scholar 

  10. Chan JR, Phillips LJ. 2nd, Glaser M. Glucocorticoids and progestins signal the initiation and enhance the rate of myelin formation. Proc Natl Acad Sci U S A 1998, 95: 10459–64.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  11. Horwitz KB, Alexander PS. In situ photolinked nuclear progesterone receptors of human breast cancer cells: subunit molecular weights after transformation and translocation. Endocrinology 1983, 113: 2195–201.

    Article  CAS  PubMed  Google Scholar 

  12. Kastner P, Krust A, Turcotte B, et al. Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. Embo J 1990, 9: 1603–14.

    CAS  PubMed Central  PubMed  Google Scholar 

  13. Vegeto E, Shahbaz MM, Wen D, Goldman ME, O’Malley BW, McDonnell DP. Human progesterone receptor A form is a cell- and promoter-specific repressor of human progesterone receptor B function [see comments]. Mol Endocrinol 1993, 7: 1244–55.

    CAS  PubMed  Google Scholar 

  14. Sartorius CA, Melville MY, Hovland AR, Tung L, Takimoto GS, Horwitz KB. A third transactivation function (AF3) of human progesterone receptors located in the unique Nterminal segment of the B-isoform. Mol Endocrinol 1994, 8: 1347–60.

    CAS  PubMed  Google Scholar 

  15. Kraus WL, Weis KE, Katzenellenbogen BS. Inhibitory crosstalk between steroid hormone receptors: differential targeting of estrogen receptor in the repression of its transcriptional activity by agonist- and antagonist-occupied progestin receptors. Mol Cell Biol 1995, 15: 1847–57.

    CAS  PubMed Central  PubMed  Google Scholar 

  16. McDonnell DP, Goldman ME. RU486 exerts antiestrogenic activities through a novel progesterone receptor A formmediated mechanism. J Biol Chem 1994, 269: 11945–9.

    CAS  PubMed  Google Scholar 

  17. McDonnell DP, Shahbaz MM, Vegeto E, Goldman ME. The human progesterone receptor A-form functions as a transcriptional modulator of mineralocorticoid receptor transcriptional activity. J Steroid Biochem Mol Biol 1994, 48: 425–32.

    Article  CAS  PubMed  Google Scholar 

  18. Rausing A, Ybo W, Stenflo J. Intracranial meningioma—a population study of ten years. Acta Neurol Scand 1970, 46: 102–10.

    Article  CAS  PubMed  Google Scholar 

  19. Michelsen JJ, New PF. Brain tumour and pregnancy. J Neurol Neurosurg Psychiatry 1969, 32: 305–7.

    CAS  PubMed Central  PubMed  Google Scholar 

  20. Hilbig A, Barbosa-Coutinho LM. Meningiomas and hormonal receptors. Immunohistochemical study in typical and non-typical tumors. Arq Neuropsiquiatr 1998, 56: 193–9.

    Article  CAS  PubMed  Google Scholar 

  21. Carroll RS, Zhang J, Dashner K, Sar M, Black PM. Steroid hormone receptors in astrocytic neoplasms. Neurosurgery 1995, 37: 496–503; discussion 503-4.

    Article  CAS  PubMed  Google Scholar 

  22. Hsu DW, Efird JT, Hedley-Whyte ET. Progesterone and estrogen receptors in meningiomas: prognostic considerations. J Neurosurg 1997, 86: 113–20.

    Article  CAS  PubMed  Google Scholar 

  23. Fewings PE, Battersby RD, Timperley WR. Long-term follow up of progesterone receptor status in benign meningioma: a prognostic indicator of recurrence? J Neurosurg 2000, 92: 401–5.

    Article  CAS  PubMed  Google Scholar 

  24. Khalid H, Shibata S, Kishikawa M, Yasunaga A, Iseki M, Hiura T. Immunohistochemical analysis of progesterone receptor and Ki-67 labeling index in astrocytic tumors. Cancer 1997, 80: 2133–40.

    Article  CAS  PubMed  Google Scholar 

  25. Assimakopoulou M, Sotiropoulou-Bonikou G, Maraziotis T, Varakis J. Does sex steroid receptor status have any prognostic or predictive significance in brain astrocytic tumors? Clin Neuropathol 1998, 17: 27–34.

    CAS  PubMed  Google Scholar 

  26. Viville B, Charnock-Jones DS, Sharkey AM, Wetzka B, Smith SK. Distribution of the A and B forms of the progesterone receptor messenger ribonucleic acid and protein in uterine leiomyomata and adjacent myometrium. Hum Reprod 1997, 12: 815–22.

    Article  CAS  PubMed  Google Scholar 

  27. Kumar NS, Richer J, Owen G, Litman E, Horwitz KB, Leslie KK. Selective down-regulation of progesterone receptor isoform B in poorly differentiated human endometrial cancer cells: implications for unopposed estrogen action. Cancer Res 1998, 58: 1860–5.

    CAS  PubMed  Google Scholar 

  28. Leslie KK, Kumar NS, Richer J, et al. Differential expression of the A and B isoforms of progesterone receptor in human endometrial cancer cells. Only progesterone receptor B is induced by estrogen and associated with strong transcriptional activation. Ann N Y Acad Sci 1997, 828: 17–26.

    Article  CAS  PubMed  Google Scholar 

  29. Akahira J, Inoue T, Suzuki T, et al. Progesterone receptor isoforms A and B in human epithelial ovarian carcinoma: immunohistochemical and RT-PCR studies. Br J Cancer 2000, 83: 1488–94.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  30. Ariga N, Suzuki T, Moriya T, et al. Progesterone receptor A and B isoforms in the human breast and its disorders. Jpn J Cancer Res 2001, 92: 302–8.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Tohoku University School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Tsukasa Inoue & H. Sasano

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  1. Tsukasa Inoue
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  2. H. Sasano
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Correspondence to Tsukasa Inoue.

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Inoue, T., Sasano, H. Possible effects of progesterone on human central nervous system and neurogenic tumors. J Endocrinol Invest 27, 76–79 (2004). https://doi.org/10.1007/BF03350916

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