Abstract
Erythrocyte sodium-lithium countertransport was evaluated in three adult patients with Bartter’s syndrome, diagnosed on clinical and histopathological basis and on laboratory tests. As compared with age-matched control subjects, lithium effluxes to both sodium medium and to sodum-free medium were high in two patients and Na+-Li+ countertransport was significantly greater in all three patients. The relationship between increased Na+-Li+ countertransport and the proposed primary disorder of Bartter’s syndrome (i.e., a primary tubular defect of chloride reabsorption) is not apparent. However, this finding favours the hypothesis of a generalized cellular membrane dysfunction of ion transport in Bartter’s syndrome.
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References
Bartter F.C. Bartter’s syndrome: a disorder of vascular reactivity. Hypertension 3 (Suppl. 1): 69, 1981.
Verberckmoes R., Van Damme B., Clement J., Amery A., Michielsen P. Bartter’s syndrome with hyperplasia of renomedullary cells. Successful treatment with indomethacin. Kidney Int. 69: 302, 1976.
Gill J.R. Jr., Frolich J.C., Bowden R.E., Taylor A.A., Keiser H.R., Seyberth H.W., Oates J.A., Bartter F.C. Bartter’s syndrome: a disorder characterized by high urinary prostaglandins and a dependence of hyperre-ninemia on prostaglandin synthesis. Am. J. Med. 67: 43, 1976.
Dray F. Bartter’s syndrome: contrasting patterns of prostaglandin excretion in children and adults. Clin. Sci. Mol. Med. 54: 115, 1978.
Vinci J.M., Gill J.R. Jr., Bowden R.E., Pisano J.J., Izzo J.L., Radfar N., Taylor A.A., Zusman R.M., Bartter F.C, Keiser H.R. The Kallikrein-Kinin system in Bartter’s syndrome and its response to prostaglandin synthetase inhibition. J. Clin. Invest. 67: 1671, 1978.
Lechi A., Covi G., Lechi C., Mantero F., Scuro L.A. Urinary Kallikrein excretion in Bartter’s syndrome. J. Clin. Endocrinol. Metab. 43: 1175, 1976.
Gardner J., Lapey A., Simopoulos A., and Bravo E. Evidence for a primary disturbance of membrane transport in Bartter’s syndrome and Liddle’s syndrome. J. Clin. Invest. 49: 32a, 1970.
Garay R.P., Elghozi J., Dagher G., Meyer P. Laboratory distinction between essential and secondary hypertension by measurement of erythrocyte cation fluxes. N. Engl. J. Med. 302: 769, 1980.
Canessa M., Adragna N., Solomon H.S., Connolly T.M., Tosteson D.C. Increased sodium-lithium countertransport in red cells of patients with essential hypertension. N. Engl. J. Med. 302: 772, 1980.
Ciabattoni G., Pugliese F., Spaldi M., Cinotti G.A., Patrono C. Radioimmunoassay measurement of prostaglandins E2 and F2 in human urine. J. Endocrinol. Invest. 2: 173, 1979.
Duhm J., Gobel B.O., Lorenz R. and Weber P.C. Sodium-lithium exchange and sodium-potassium co- transport in human erythrocytes. Part. 2: A simple uptake test applied to normotensive and essential hypertensive individuals. Hypertension 4: 411, 1982.
Canessa M., Adragna N., Bize J., Connolly T., Solomon H., Williams G., Slater E. and Tosteson D.C. Ouabain-insensitive cation transport in the red cells of normotensive and hypertensive subjects. In: H. Zumkley and H. Losse (Eds.), Intracellular Electro lytes and arterial hypertension. Georg Thieme Verlag, Stuttgard, 1980, p. 239.
Gall G., Vaitukaitis J., Haddow J.E., Klein R., Erythrocyte Na+ flux in a patient with Bartter’s syn drome. J. Clin. Endocrinol. Metab. 32: 563, 1971.
Sigstrom L., Enger E., Haljamae H. Membrane disfunction of cation transport in Bartter’s syndrome. Scand. J. Clin. Lab. Invest. 57: 1565, 1972.
Chipperfield A.R. An effect of chloride on (Na + K) co-transport in human red blood cells. Nature 276: 281, 1980.
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Mattioli, M., Delva, P., Lechi, C. et al. Increased sodium-lithium countertransport in red cells of patients with Bartter’s syndrome. J Endocrinol Invest 7, 61–63 (1984). https://doi.org/10.1007/BF03348379
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DOI: https://doi.org/10.1007/BF03348379