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Insulin resistance is independently related to age in Mexican women

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Abstract

Whether the decrease of insulin action is a biological consequence of age or a result of lifestyle changes in elderly people is uncertain. Therefore, we rigorously controlled potential confounders to evaluate the relationship between age and insulin resistance in Mexican women. A total of 100 glucose-tolerant, non-hypertensive women, 30–65 yr of age, inhabitants of the same neighborhood of Durango, a city in the North of Mexico, were randomly enrolled to participate in a case-control study. The study was designed to include 50 cases and 50 controls. Insulin-resistant women were considered as cases and compared vs a control group of non-insulin resistant women, matched by BMI and Waist-to-Hip ratio (WHR). HOMA-IR index equal or greater than 3.0 defined the presence of insulin resistance. Endocrine diseases, pregnancy, smoking, alcohol consumption, and physical activity were exclusion criteria. The results showed insulin resistant women were significantly older than control women (53.7±12.2 vs 46.3±10.4, p=0.0004). Women in the case group showed a direct correlation between age and HOMA-IR index (0.427, p=0.02), whereas control women did not (0.09, p=0.626). Step-wise forward selection logistic regression analysis showed an independent relationship between HOMA-IR index and age (OR 1.5, CI95% 1.4–1.8, p=0.002). The results of this study show an independent relationship between age and high HOMA-IR index in Mexican women, supporting the hypothesis that age per se could be associated with the impairment of insulin action.

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References

  1. Muller D.C., Elahi D., Tobin J.D., Andres R. The effect of age on insulin resistance and secretion: a review. Semin. Nephrol. 1996, 16: 289–298.

    PubMed  CAS  Google Scholar 

  2. Ferrannini E., Vichi S., Beck-Nielsen H., Laakso M., Paolisso G., Smith U. Insulin action and age. European Group for the Study of Insulin Resistance (EGIR). Diabetes 1996, 45: 947–953.

    Article  PubMed  CAS  Google Scholar 

  3. Lönnroth P., Smith U. Aging enhances the insulin resistance in obesity through both receptor and postreceptor alterations. J. Clin. Endocrinol. Metab. 1986, 62: 433–437.

    Article  PubMed  Google Scholar 

  4. Kohrt W.M., Kirwan J.P., Staten M.A., Bourey R.E., King D.S., Holloszy J.O. Insulin resistance in aging is related to abdominal obesity. Diabetes 1993, 42: 273–281.

    Article  PubMed  CAS  Google Scholar 

  5. Craig B.W., Garthwaite S.M., Holloszy J.O. Adipocyte insulin resistance: effects of aging, obesity, exercise, and food restriction. J. Appl. Physiol. 1987, 62: 95–100.

    Article  PubMed  CAS  Google Scholar 

  6. O’Shaughnessy I.M., Kasdorf G.M., Hoffmann R.G., Kalkhoff R.K. Does aging intensify the insulin resistance of human obesity? J. Clin. Endocrinol. Metab. 1992, 74: 1075–1081.

    Article  PubMed  Google Scholar 

  7. Dechenes C.J., Verchere C.B., Andrikopoulos S., Kahn S.E. Human aging is associated with parallel reductions in insulin and amylin release. Am. J. Physiol. 1998, 275: Pt 1 E785–E791.

    PubMed  CAS  Google Scholar 

  8. Iozzo P., Beck-Nielsen H., Laakso M., Smith U., Yki-Järvinen H., Ferrannini E. Independent influence of age on basa insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance. J. Clin. Endocrinol. Metab. 1999, 84: 863–868.

    Article  PubMed  CAS  Google Scholar 

  9. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1999, 21 (1): 5–20.

    Google Scholar 

  10. The Sixth Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Arch. Intern. Med. 1997, 157: 2413–2446.

    Article  Google Scholar 

  11. Rodríguez B.L., Curv D., Burchfield C.M. et al. Physical activity and 23-year incidence morbidity and mortality among middle-aged men. Circulation 1994, 89: 2540–2544.

    Article  PubMed  Google Scholar 

  12. Matthews D., Hosker J., Rudenski A., Naylor B., Treacher D., Turner R. Homeostasis Model Assessment: Insulin resistance and B-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985, 28: 412–419.

    Article  PubMed  CAS  Google Scholar 

  13. Sonnenschein E., Toniolo P., Terry M.B. et al. Body fat distribution and obesity in pre- and postmenopausal breast cancer. Int. J. Epidemiol. 1999, 28: 1026–1031.

    Article  PubMed  CAS  Google Scholar 

  14. Kramer M.S. Clinical Epidemiology and Biostatistics. Springer-Verlag, Berlin, Heidelberg, 1988: 93–112.

    Book  Google Scholar 

  15. O’Hare J.A. The enigma of insulin resistance and hypertension. Insulin resistance, blood pressure, and the circulation. Am. J. Med. 1988, 84: 3 pt 1, 505–510.

    Article  PubMed  Google Scholar 

  16. Lazarus R., Sparrow D., Weiss S.T. Alcohol intake and insulin levels. The normative aging study. Am. J. Epidemiol. 1997, 145: 909–916.

    Article  PubMed  CAS  Google Scholar 

  17. Rosenthal M., Hakel W.L., Solomon R., Widstrom A., Reaven G.M. Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans. Diabetes 1983, 32: 408–411.

    Article  PubMed  CAS  Google Scholar 

  18. Tapia-Conyer R. Encuesta Nacional de Enfermedades Crónicas. Secretaría de Salud, Dirección General de Epidemiología. México D.F., 1993, p. 19–24.

    Google Scholar 

  19. Guerrero-Romero F., Rodríguez-Morán M., González-Ortiz M., Martínez-Abundis E. Insulin action and secretion in healthy Hispanic-Mexican first-degree relatives of subjects with type 2 diabetes. J. Endocrinol. Invest. 2001, 24: 580–586.

    Article  CAS  Google Scholar 

  20. Rodríguez-Morán M., Guerrero-Romero F. Hyperinsulinemia and abdominal obesity are more prevalent in non-diabetic subjects with family history of Type 2 Diabetes. Arch. Med. Res. 2000, 31: 399–403.

    Article  PubMed  Google Scholar 

  21. Ishikawa M., Pruneda ML., Adams-Huet B., Raskin P. Obesity-independent hyperinsulinemia in nondiabetic first-degree relatives of individuals with type 2 diabetes. Diabetes 1998, 47: 788–792.

    Article  PubMed  CAS  Google Scholar 

  22. Rodríguez-Morán M., Guerrero-Romero F. The parenta phenotype of Diabetes, but not of Essential Hypertension, is linked to the development of Metabolic Syndrome in Mexican individuals. Acta Diabetol. 2001, 38: 87–91.

    Article  PubMed  Google Scholar 

  23. Guerrero-Romero F., Rodríguez-Morán M. Glucose intolerance is predicted by the high Fasting Insulin-to-Glucose ratio. Diabetes Metab. 2001, 27: 117–121.

    PubMed  CAS  Google Scholar 

  24. Guerrero-Romero F., Rodríguez-Morán M. La historia familiar de diabetes se asocia al incremento de la respuesta temprana de insulina, en sujetos Hispano-Mexicanos sanos. Gac. Med. Mex. 2001, 137: 529–534.

    PubMed  CAS  Google Scholar 

  25. Bonora E., Targher G., Alberiche M. et al. Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Studies in subjects with various degrees of glucose tolerance and insulin sensitivity. Diabetes Care 2000, 23: 57–63.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medical Research Unit in Clinical Epidemiology of the Mexican Social Security Institute, Siqueiros 225 esq/Castañeda, 34000, Durango, Dgo., Mexico

    Martha Rodríguez-Morán & F. Guerrero-Romero

  2. Research Group on Diabetes and Chronic Illnesses, Durango, Mexico

    Martha Rodríguez-Morán & F. Guerrero-Romero

Authors
  1. Martha Rodríguez-Morán
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  2. F. Guerrero-Romero
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Correspondence to Martha Rodríguez-Morán.

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Rodríguez-Morán, M., Guerrero-Romero, F. Insulin resistance is independently related to age in Mexican women. J Endocrinol Invest 26, 42–48 (2003). https://doi.org/10.1007/BF03345121

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