Skip to main content
SpringerLink
Log in

The importance of investigation of pituitary function in children and adolescents following traumatic brain injury

  • Congress Report
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

Abstract

It is now widely accepted that brain injuries are often the cause of acquired hypopituitarism in adulthood. The information about the pituitary function in brain-injured children and adolescence is however scanty. An international workshop entitled “Traumatic brain injury and hypopituitarism” was held on 9–10 April 2006 in Granada, Spain, in order to explore the relatively unknown but potentially important field of investigation, diagnosis and treatment of pituitary deficiency in children and adolescents following traumatic brain injury (TBI). The following conclusions were reached: 1) a prospective pediatric and adolescent study of pituitary function was indicated; 2) close collaboration among neurosurgeons, neurologists, rehabilitation specialists and pediatric endocrinologists, with support from adult endocrinologists, is essential to achieve a coordinated approach to the care of children after TBI; 3) a model of interaction, similar to that now existing with oncologists, needs to be established; 4) a “pediatric TBI late-effects” service should be created, preferably led by endocrinologists, so that knowledge of growth and puberty can be included, in order to optimize identification, investigation and treatment of this important group of patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Leon-Carrion J, Dominguez-Moralez MR, Barroso y Martin JM, Murillo-Cabezas F. Epidemiology of traumatic brain injury and subarachnoid haemorrhage. Pituitary 2006, 8: 197–202.

    Article  Google Scholar 

  2. Bonnefont X, Lacampagne A, Sanchez-Hormigo A, et al. Revealing the large-scale network organization of growth hormone-secreting cells. Proc Natl Acad Sci U S A 2005, 102: 16880–5.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Ghigo E, Masel B, Aimaretti G, et al. Consensus guidelines on screening for hypopituitarism following traumatic brain injury. Brain Inj 2005, 19: 711–24.

    Article  CAS  PubMed  Google Scholar 

  4. Popovic V, Aimaretti G, Casanueva FF, Ghigo E. Hypopituitarism following traumatic brain injury. Growth Horm IGF Res 2005, 15: 177–84.

    Article  CAS  PubMed  Google Scholar 

  5. Masel BE. Traumatic brain injury induced hypopituitarism: The need and hope of rehabilitation. Pituitary 2006, 8: 263–6.

    Article  Google Scholar 

  6. Schneider HJ, Schneider M, Saller B, et al. Eur J Endocrinol 2006, 154: 259–65.

    Article  CAS  PubMed  Google Scholar 

  7. Agha A, Rogers B, Sherlock M, et al. Anterior pituitary dysfunction in survivors of traumatic brain injury. J Clin Endocrinol Metab 2004, 89: 4929–36.

    Article  CAS  PubMed  Google Scholar 

  8. Lieberman SA, Oberoi AL, Gilkison CR, Masel B, Urban RJ. Prevalence of neuroendocrine dysfunction in patients recovering from traumatic brain injury. J Clin Endocrinol Metab 2001, 86: 2752–6.

    CAS  PubMed  Google Scholar 

  9. Kestimur F. Chronic trauma in sports as a cause of hypopituitarism. Pituitary 2005, 8: 259–62.

    Article  Google Scholar 

  10. Miller WL, Kaplan SL, Grumbach MM. Child abuse as a cause of post-traumatic hypopituitarism. N Engl J Med 1980, 302: 724–8.

    Article  CAS  PubMed  Google Scholar 

  11. Benvenga S, Campenni A, Ruggeri RM, Trimarchi F. Hypopituitarism secondary to head trauma. J Clin Endocrinol Metab 2000, 85: 1353–61.

    Article  CAS  PubMed  Google Scholar 

  12. Barbeau C, Jouret B, Gallegos D, et al. Syndrome d’interruption de la tige pituitarire. Arch Pédiatr 1998, 5: 274–9.

    Article  CAS  PubMed  Google Scholar 

  13. Aimaretti G, Ambrosio MR, Di Somma C, et al. Residual pituitary function after brain-injury induced hypopituitarism: a prospective 12 month study. J Clin Endocrinol Metab 2005, 90: 6085–92.

    Article  CAS  PubMed  Google Scholar 

  14. Aimaretti G, Ambrosio MR, Di Somma C, et al. Hypopituitarism induced by traumatic brain injury in the transitio phase. J Endocrinological Invest 2005, 28: 984–9.

    Article  CAS  Google Scholar 

  15. Casanueva FF, Ghigo E, Popovic V, et al. Athens TBI and Hypopituitarism study group. J Endocrinol Invest 2004, 27: 793–5.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Endocrinology, Department of Medicine and Complejo Hospitalariode Santiago, Santiago de Compostela, Spain

    F. F. Casanueva

  2. Division of Endocrinology, Department of Internal Medicine, University of Turin, Turin, Italy

    E. Ghigo

  3. Service of Pediatric Endocrinology, Hôpital Necker-Enfants Malades, Paris, France

    M. Polak

  4. Department of Endocrinology, St Bartholomew’s, London School of Medicine and Dentistry, London, UK

    M. O. Savage

Authors
  1. F. F. Casanueva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Ghigo
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Polak
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. O. Savage
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to M. O. Savage.

Additional information

Meeting report from the international workshop: “Traumatic brain injury and hypopituitarism” held in Granada — Spain 9–10 April 2006.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Casanueva, F.F., Ghigo, E., Polak, M. et al. The importance of investigation of pituitary function in children and adolescents following traumatic brain injury. J Endocrinol Invest 29, 764–766 (2006). https://doi.org/10.1007/BF03344190

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03344190

En]Keywords

Search

Navigation